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Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations.
Koyano S, Kurose K, Ozawa S, Saeki M, Nakajima Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Nakajima T, Saito H, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Saito Y, Sawada J. Koyano S, et al. Among authors: ohnuma t. Drug Metab Pharmacokinet. 2002;17(6):561-5. doi: 10.2133/dmpk.17.561. Drug Metab Pharmacokinet. 2002. PMID: 15618712 Free article.
Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.
Soyama A, Saito Y, Hanioka N, Maekawa K, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Ueno K, Goto Y, Kimura H, Katoh M, Sugai K, Saitoh O, Kawai M, Ohnuma T, Ohtsuki T, Suzuki C, Minami N, Kamatani N, Ozawa S, Sawada J. Soyama A, et al. Among authors: ohnuma t. Drug Metab Pharmacokinet. 2005 Feb;20(1):24-33. doi: 10.2133/dmpk.20.24. Drug Metab Pharmacokinet. 2005. PMID: 15770072 Free article.
Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.
Murayama N, Soyama A, Saito Y, Nakajima Y, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Ozawa S, Sawada J. Murayama N, et al. Among authors: ohnuma t. J Pharmacol Exp Ther. 2004 Jan;308(1):300-6. doi: 10.1124/jpet.103.055798. Epub 2003 Oct 16. J Pharmacol Exp Ther. 2004. PMID: 14563787
Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.
Nakajima Y, Saito Y, Shiseki K, Fukushima-Uesaka H, Hasegawa R, Ozawa S, Sugai K, Katoh M, Saitoh O, Ohnuma T, Kawai M, Ohtsuki T, Suzuki C, Minami N, Kimura H, Goto Y, Kamatani N, Kaniwa N, Sawada J. Nakajima Y, et al. Among authors: ohnuma t. Eur J Clin Pharmacol. 2005 Mar;61(1):25-34. doi: 10.1007/s00228-004-0878-1. Epub 2005 Feb 4. Eur J Clin Pharmacol. 2005. PMID: 15692831 Clinical Trial.
483 results