McGuire JJ - Search Results

1

Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Gangjee A, Zeng Y, McGuire JJ, Mehraein F, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2004 Dec 30;47(27):6893-901. doi: 10.1021/jm040123k. J Med Chem. 2004. PMID: 15615538

2

Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2002 Apr 25;45(9):1942-8. doi: 10.1021/jm010575m. J Med Chem. 2002. PMID: 11960504

3

Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2002 Nov 7;45(23):5173-81. doi: 10.1021/jm0202369. J Med Chem. 2002. PMID: 12408727

4

Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.

Gangjee A, Yu J, Kisliuk RL, Haile WH, Sobrero G, McGuire JJ. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2003 Feb 13;46(4):591-600. doi: 10.1021/jm0203534. J Med Chem. 2003. PMID: 12570380

5

Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors.

Gangjee A, Dubash NP, Zeng Y, McGuire JJ. Gangjee A, et al. Among authors: mcguire jj. Curr Med Chem Anticancer Agents. 2002 May;2(3):331-55. doi: 10.2174/1568011024606352. Curr Med Chem Anticancer Agents. 2002. PMID: 12678736 Review.

6

Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.

Gangjee A, Jain HD, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2004 Dec 30;47(27):6730-9. doi: 10.1021/jm040144e. J Med Chem. 2004. PMID: 15615522

7

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2005 Aug 11;48(16):5329-36. doi: 10.1021/jm058213s. J Med Chem. 2005. PMID: 16078850 Free PMC article.

8

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.

Gangjee A, Lin X, Kisliuk RL, McGuire JJ. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2005 Nov 17;48(23):7215-22. doi: 10.1021/jm058234m. J Med Chem. 2005. PMID: 16279780

9

Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).

Gangjee A, Jain HD, Phan J, Lin X, Song X, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. J Med Chem. 2006 Feb 9;49(3):1055-65. doi: 10.1021/jm058276a. J Med Chem. 2006. PMID: 16451071 Free PMC article.

10

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.

Gangjee A, Yang J, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: mcguire jj. Bioorg Med Chem. 2006 Dec 15;14(24):8590-8. doi: 10.1016/j.bmc.2006.08.029. Epub 2006 Sep 20. Bioorg Med Chem. 2006. PMID: 16990006 Free PMC article.

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