Kisliuk RL - Search Results

1

Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Gangjee A, Zeng Y, McGuire JJ, Mehraein F, Kisliuk RL. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2004 Dec 30;47(27):6893-901. doi: 10.1021/jm040123k. J Med Chem. 2004. PMID: 15615538

2

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Zaware N, Kisliuk R, Bastian A, Ihnat MA, Gangjee A. Zaware N, et al. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1602-1607. doi: 10.1016/j.bmcl.2017.02.018. Epub 2017 Feb 11. Bioorg Med Chem Lett. 2017. PMID: 28258797 Free PMC article.

3

Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2002 Apr 25;45(9):1942-8. doi: 10.1021/jm010575m. J Med Chem. 2002. PMID: 11960504

4

Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2002 Nov 7;45(23):5173-81. doi: 10.1021/jm0202369. J Med Chem. 2002. PMID: 12408727

5

Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.

Gangjee A, Yu J, Kisliuk RL, Haile WH, Sobrero G, McGuire JJ. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2003 Feb 13;46(4):591-600. doi: 10.1021/jm0203534. J Med Chem. 2003. PMID: 12570380

6

Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.

Gangjee A, Jain HD, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2004 Dec 30;47(27):6730-9. doi: 10.1021/jm040144e. J Med Chem. 2004. PMID: 15615522

7

Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.

Gangjee A, Jain HD, Kisliuk RL. Gangjee A, et al. Among authors: kisliuk rl. Bioorg Med Chem Lett. 2005 May 2;15(9):2225-30. doi: 10.1016/j.bmcl.2005.03.029. Bioorg Med Chem Lett. 2005. PMID: 15837298

8

Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.

Gangjee A, Zeng Y, Ihnat M, Warnke LA, Green DW, Kisliuk RL, Lin FT. Gangjee A, et al. Among authors: kisliuk rl. Bioorg Med Chem. 2005 Sep 15;13(18):5475-91. doi: 10.1016/j.bmc.2005.04.087. Bioorg Med Chem. 2005. PMID: 16039863

9

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Gangjee A, Zeng Y, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2005 Aug 11;48(16):5329-36. doi: 10.1021/jm058213s. J Med Chem. 2005. PMID: 16078850 Free PMC article.

10

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.

Gangjee A, Lin X, Kisliuk RL, McGuire JJ. Gangjee A, et al. Among authors: kisliuk rl. J Med Chem. 2005 Nov 17;48(23):7215-22. doi: 10.1021/jm058234m. J Med Chem. 2005. PMID: 16279780

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