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Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.
Loan Nguyen TM, Guilloux JP, Defaix C, Mendez-David I, Etting I, Alvarez JC, McGowan JC, Highland JN, Zanos P, Lovett J, Moaddel R, Corruble E, David DJ, Gould TD, Denny CA, Gardier AM. Loan Nguyen TM, et al. Among authors: highland jn. Neuropharmacology. 2024 Nov 1;258:110065. doi: 10.1016/j.neuropharm.2024.110065. Epub 2024 Jul 14. Neuropharmacology. 2024. PMID: 39004413 Free PMC article.
Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor.
Georgiou P, Zanos P, Mou TM, An X, Gerhard DM, Dryanovski DI, Potter LE, Highland JN, Jenne CE, Stewart BW, Pultorak KJ, Yuan P, Powels CF, Lovett J, Pereira EFR, Clark SM, Tonelli LH, Moaddel R, Zarate CA Jr, Duman RS, Thompson SM, Gould TD. Georgiou P, et al. Among authors: highland jn. Nat Neurosci. 2022 Sep;25(9):1191-1200. doi: 10.1038/s41593-022-01146-x. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042309 Free PMC article.
56 results