Kane JL Jr - Search Results

1

The simultaneous inhibition of SLC6A19 and BCRP transporters leads to an increase of indoxyl sulfate (a uremic toxin) in plasma and kidney.

Wang Q, Munteanu B, Marker A, Luo Y, Holz C, Kane JL Jr, Kuntzweiler T, Poulton EJ, Sedic M, Jayyosi Z, Riedel J, Fretland J. Wang Q, et al. Among authors: kane jl jr. Drug Metab Dispos. 2024 Sep 9:DMD-AR-2024-001813. doi: 10.1124/dmd.124.001813. Online ahead of print. Drug Metab Dispos. 2024. PMID: 39251367 Free article.

2

Identification of Selective Imidazopyridine CSF1R Inhibitors.

Kane JL Jr, Asmussen G, Batchelor J, Cromwell M, Fezoui M, Fitzgerald M, Giese B, Gladysheva T, Holley S, Keefe K, Kothe M, Lam B, Lim S, Liu J, Ma L, Metz M, Scholte AA, Shum P, Wei L, Woodworth L, Edling A. Kane JL Jr, et al. ACS Med Chem Lett. 2024 Apr 30;15(5):722-730. doi: 10.1021/acsmedchemlett.4c00110. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746878

3

A Solid Supported Membrane-Based Technology for Electrophysical Screening of B⁰AT1-Modulating Compounds.

Gerbeth-Kreul C, Pommereau A, Ruf S, Kane JL Jr, Kuntzweiler T, Hessler G, Engel CK, Shum P, Wei L, Czech J, Licher T. Gerbeth-Kreul C, et al. Among authors: kane jl jr. SLAS Discov. 2021 Jul;26(6):783-797. doi: 10.1177/24725552211011180. Epub 2021 May 6. SLAS Discov. 2021. PMID: 33955247 Free article.

4

Discovery of novel sphingosine kinase-1 inhibitors. Part 2.

Xiang Y, Hirth B, Kane JL Jr, Liao J, Noson KD, Yee C, Asmussen G, Fitzgerald M, Klaus C, Booker M. Xiang Y, et al. Among authors: kane jl jr. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4. doi: 10.1016/j.bmcl.2010.06.019. Epub 2010 Jun 17. Bioorg Med Chem Lett. 2010. PMID: 20598880

5

Discovery of novel sphingosine kinase 1 inhibitors.

Xiang Y, Asmussen G, Booker M, Hirth B, Kane JL Jr, Liao J, Noson KD, Yee C. Xiang Y, et al. Among authors: kane jl jr. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21. doi: 10.1016/j.bmcl.2009.09.022. Epub 2009 Sep 10. Bioorg Med Chem Lett. 2009. PMID: 19800228

6

Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport.

Hirth BH, Qiao S, Cuff LM, Cochran BM, Pregel MJ, Gregory JS, Sneddon SF, Kane JL Jr. Hirth BH, et al. Among authors: kane jl jr. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2087-91. doi: 10.1016/j.bmcl.2005.02.041. Bioorg Med Chem Lett. 2005. PMID: 15808474

7

Ring expansion-annulation strategy for the synthesis of substituted azulenes and oligoazulenes. 2. Synthesis of azulenyl halides, sulfonates, and azulenylmetal compounds and their application in transition-metal-mediated coupling reactions.

Crombie AL, Kane JL Jr, Shea KM, Danheiser RL. Crombie AL, et al. Among authors: kane jl jr. J Org Chem. 2004 Dec 10;69(25):8652-67. doi: 10.1021/jo048698c. J Org Chem. 2004. PMID: 15575741

8

Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.

Kane JL Jr, Hirth BH, Liang B, Gourlie BB, Nahill S, Barsomian G. Kane JL Jr, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4463-6. doi: 10.1016/j.bmcl.2003.09.013. Bioorg Med Chem Lett. 2003. PMID: 14643347

9

A ring expansion-annulation strategy for the synthesis of substituted azulenes. Preparation and Suzuki coupling reactions of 1-azulenyl triflates.

Kane JL Jr, Shea KM, Crombie AL, Danheiser RL. Kane JL Jr, et al. Org Lett. 2001 Apr 5;3(7):1081-4. doi: 10.1021/ol0156897. Org Lett. 2001. PMID: 11277800

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