Humblet C - Search Results

1

Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.

Ortwine DF, Malone TC, Bigge CF, Drummond JT, Humblet C, Johnson G, Pinter GW. Ortwine DF, et al. Among authors: humblet c. J Med Chem. 1992 Apr 17;35(8):1345-70. doi: 10.1021/jm00086a004. J Med Chem. 1992. PMID: 1533422

2

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: humblet c. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

3

A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs.

Lunney EA, Hagen SE, Domagala JM, Humblet C, Kosinski J, Tait BD, Warmus JS, Wilson M, Ferguson D, Hupe D, et al. Lunney EA, et al. Among authors: humblet c. J Med Chem. 1994 Aug 19;37(17):2664-77. doi: 10.1021/jm00043a006. J Med Chem. 1994. PMID: 8064795

4

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. Pavlovsky AG, et al. Among authors: humblet c. Protein Sci. 1999 Jul;8(7):1455-62. doi: 10.1110/ps.8.7.1455. Protein Sci. 1999. PMID: 10422833 Free PMC article.

5

4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.

Jaen JC, Wise LD, Caprathe BW, Tecle H, Bergmeier S, Humblet CC, Heffner TG, Meltzer LT, Pugsley TA. Jaen JC, et al. Among authors: humblet cc. J Med Chem. 1990 Jan;33(1):311-7. doi: 10.1021/jm00163a051. J Med Chem. 1990. PMID: 1967314

6

Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.

Repine JT, Kaltenbronn JS, Doherty AM, Hamby JM, Himmelsbach RJ, Kornberg BE, Taylor MD, Lunney EA, Humblet C, Rapundalo ST, et al. Repine JT, et al. Among authors: humblet c. J Med Chem. 1992 Mar 20;35(6):1032-42. doi: 10.1021/jm00084a008. J Med Chem. 1992. PMID: 1552498

7

Highly selective kappa opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity.

Halfpenny PR, Horwell DC, Hughes J, Humblet C, Hunter JC, Neuhaus D, Rees DC. Halfpenny PR, et al. Among authors: humblet c. J Med Chem. 1991 Jan;34(1):190-4. doi: 10.1021/jm00105a028. J Med Chem. 1991. PMID: 1846919

8

4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.

Tait BD, Hagen S, Domagala J, Ellsworth EL, Gajda C, Hamilton HW, Prasad JV, Ferguson D, Graham N, Hupe D, Nouhan C, Tummino PJ, Humblet C, Lunney EA, Pavlovsky A, Rubin J, Gracheck SJ, Baldwin ET, Bhat TN, Erickson JW, Gulnik SV, Liu B. Tait BD, et al. Among authors: humblet c. J Med Chem. 1997 Nov 7;40(23):3781-92. doi: 10.1021/jm970615f. J Med Chem. 1997. PMID: 9371244

9

Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.

Repine JT, Himmelsbach RJ, Hodges JC, Kaltenbronn JS, Sircar I, Skeean RW, Brennan ST, Hurley TR, Lunney E, Humblet CC, et al. Repine JT, et al. Among authors: humblet cc. J Med Chem. 1991 Jul;34(7):1935-43. doi: 10.1021/jm00111a002. J Med Chem. 1991. PMID: 2066966

10

Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.

Trumpp-Kallmeyer S, Rubin JR, Humblet C, Hamby JM, Showalter HD. Trumpp-Kallmeyer S, et al. Among authors: humblet c. J Med Chem. 1998 May 21;41(11):1752-63. doi: 10.1021/jm970634p. J Med Chem. 1998. PMID: 9599227

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