Laping NJ - Search Results

1

SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.

Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, Reese ED, Herbstreith MH, Laping NJ, Friedman HS, Bigner DD, Wang XF, Rich JN. Hjelmeland MD, et al. Among authors: laping nj. Mol Cancer Ther. 2004 Jun;3(6):737-45. Mol Cancer Ther. 2004. PMID: 15210860

2

Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.

Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, McDonnell DP. Sherk AB, et al. Among authors: laping nj. Cancer Res. 2008 Sep 15;68(18):7475-83. doi: 10.1158/0008-5472.CAN-08-1047. Cancer Res. 2008. PMID: 18794135 Free PMC article.

3

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

DaCosta Byfield S, Major C, Laping NJ, Roberts AB. DaCosta Byfield S, et al. Among authors: laping nj. Mol Pharmacol. 2004 Mar;65(3):744-52. doi: 10.1124/mol.65.3.744. Mol Pharmacol. 2004. PMID: 14978253

4

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA. Laping NJ, et al. Mol Pharmacol. 2002 Jul;62(1):58-64. doi: 10.1124/mol.62.1.58. Mol Pharmacol. 2002. PMID: 12065755

5

Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis.

Grygielko ET, Martin WM, Tweed C, Thornton P, Harling J, Brooks DP, Laping NJ. Grygielko ET, et al. Among authors: laping nj. J Pharmacol Exp Ther. 2005 Jun;313(3):943-51. doi: 10.1124/jpet.104.082099. Epub 2005 Mar 15. J Pharmacol Exp Ther. 2005. PMID: 15769863

6

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. Inman GJ, et al. Among authors: laping nj. Mol Pharmacol. 2002 Jul;62(1):65-74. doi: 10.1124/mol.62.1.65. Mol Pharmacol. 2002. PMID: 12065756

7

The role of transforming growth factor-beta and its receptors in human prostate smooth muscle cell fibronectin production.

Butter S, Laping NJ, Pullen M, Grygielko E, Olson B, Brooks DP. Butter S, et al. Among authors: laping nj. Eur J Pharmacol. 2001 Jun 22;422(1-3):47-52. doi: 10.1016/s0014-2999(01)01072-x. Eur J Pharmacol. 2001. PMID: 11430912

8

Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats.

Laping NJ, Everitt JI, Frazier KS, Burgert M, Portis MJ, Cadacio C, Gold LI, Walker CL. Laping NJ, et al. Clin Cancer Res. 2007 May 15;13(10):3087-99. doi: 10.1158/1078-0432.CCR-06-1811. Clin Cancer Res. 2007. PMID: 17505012

9

Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ. Callahan JF, et al. Among authors: laping nj. J Med Chem. 2002 Feb 28;45(5):999-1001. doi: 10.1021/jm010493y. J Med Chem. 2002. PMID: 11855979

10

Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.

Gellibert F, de Gouville AC, Woolven J, Mathews N, Nguyen VL, Bertho-Ruault C, Patikis A, Grygielko ET, Laping NJ, Huet S. Gellibert F, et al. Among authors: laping nj. J Med Chem. 2006 Apr 6;49(7):2210-21. doi: 10.1021/jm0509905. J Med Chem. 2006. PMID: 16570917

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