Lieu L - Search Results

1

Enhanced Payload Localization in Antibody-Drug Conjugates Using a Middle-Down Mass Spectrometry Approach with Proton Transfer Charge Reduction.

Lieu LB, Nagy C, Huang J, Mullen C, McAlister GC, Zabrouskov V, Srzentić K, Durbin KR, Melani RD, Fornelli L. Lieu LB, et al. Anal Chem. 2024 Nov 19;96(46):18483-18490. doi: 10.1021/acs.analchem.4c03872. Epub 2024 Nov 7. Anal Chem. 2024. PMID: 39511732

2

Leveraging Ion-Ion and Ion-Photon Activation to Improve the Sequencing of Proteins Carrying Multiple Disulfide Bonds: The Human Serum Albumin Case Study.

Lieu LB, Hinkle JD, Syka JEP, Fornelli L. Lieu LB, et al. J Am Soc Mass Spectrom. 2024 Nov 7. doi: 10.1021/jasms.4c00391. Online ahead of print. J Am Soc Mass Spectrom. 2024. PMID: 39508460

3

NMDA Receptors in POMC Neurons Connect Exercise With Insulin Sensitivity.

Portillo B, Hwang E, Ajwani J, Grose K, Lieu L, Wallace B, Kabahizi A, Elmquist JK, Williams KW. Portillo B, et al. Among authors: lieu l. Diabetes. 2024 Dec 1;73(12):1942-1951. doi: 10.2337/dbi24-0002. Diabetes. 2024. PMID: 39401391 Free PMC article. Review.

4

Towards a universal method for middle-down analysis of antibodies via proton transfer charge reduction-Orbitrap mass spectrometry.

Oates RN, Lieu LB, Kline JT, Mullen C, Srzentić K, Huguet R, McAlister GC, Huang J, Bergen D, Melani RD, Zabrouskov V, Durbin KR, Syka JEP, Fornelli L. Oates RN, et al. Among authors: lieu lb. Anal Bioanal Chem. 2024 Nov;416(28):6463-6472. doi: 10.1007/s00216-024-05534-z. Epub 2024 Sep 16. Anal Bioanal Chem. 2024. PMID: 39283368

5

Top-down mass spectrometry analysis of capsid proteins of recombinant adeno-associated virus using multiple ion activations and proton transfer charge reduction.

Kline JT, Huang J, Lieu LB, Srzentić K, Bergen D, Mullen C, McAlister GC, Durbin KR, Melani RD, Fornelli L. Kline JT, et al. Among authors: lieu lb. Proteomics. 2024 Sep 5:e2400223. doi: 10.1002/pmic.202400223. Online ahead of print. Proteomics. 2024. PMID: 39233542

6

Upregulation of Xbp1 in NPY/AgRP neurons reverses diet-induced obesity and ameliorates leptin and insulin resistance.

Ajwani J, Hwang E, Portillo B, Lieu L, Wallace B, Kabahizi A, He Z, Dong Y, Grose K, Williams KW. Ajwani J, et al. Among authors: lieu l. Neuropeptides. 2024 Dec;108:102461. doi: 10.1016/j.npep.2024.102461. Epub 2024 Aug 6. Neuropeptides. 2024. PMID: 39180950

7

Characterization of a Monoclonal Antibody by Native and Denaturing Top-Down Mass Spectrometry.

Oates RN, Lieu LB, Srzentić K, Damoc E, Fornelli L. Oates RN, et al. Among authors: lieu lb. J Am Soc Mass Spectrom. 2024 Sep 4;35(9):2197-2208. doi: 10.1021/jasms.4c00224. Epub 2024 Aug 6. J Am Soc Mass Spectrom. 2024. PMID: 39105725

8

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.

Dong Y, Carty J, Goldstein N, He Z, Hwang E, Chau D, Wallace B, Kabahizi A, Lieu L, Peng Y, Gao Y, Hu L, Betley JN, Williams KW. Dong Y, et al. Among authors: lieu l. Mol Metab. 2021 Dec;54:101352. doi: 10.1016/j.molmet.2021.101352. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626854 Free PMC article.

9

PERK in POMC neurons connects celastrol with metabolism.

He Z, Lieu L, Dong Y, Afrin S, Chau D, Kabahizi A, Wallace B, Cao J, Hwang ES, Yao T, Huang Y, Okolo J, Cheng B, Gao Y, Hu L, Williams KW. He Z, et al. Among authors: lieu l. JCI Insight. 2021 Sep 22;6(18):e145306. doi: 10.1172/jci.insight.145306. JCI Insight. 2021. PMID: 34549728 Free PMC article.

10

Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics.

Kabahizi A, Wallace B, Lieu L, Chau D, Dong Y, Hwang ES, Williams KW. Kabahizi A, et al. Among authors: lieu l. Br J Pharmacol. 2022 Feb;179(4):600-624. doi: 10.1111/bph.15682. Epub 2021 Nov 4. Br J Pharmacol. 2022. PMID: 34519026 Free PMC article. Review.

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