He K - Search Results

1

Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.

He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF. He K, et al. Drug Metab Dispos. 2004 Jun;32(6):639-46. doi: 10.1124/dmd.32.6.639. Drug Metab Dispos. 2004. PMID: 15155556

2

Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.

He K, Talaat RE, Woolf TF. He K, et al. Drug Metab Dispos. 2004 Apr;32(4):442-6. doi: 10.1124/dmd.32.4.442. Drug Metab Dispos. 2004. PMID: 15039298

3

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.

Zhang D, Raghavan N, Chen SY, Zhang H, Quan M, Lecureux L, Patrone LM, Lam PY, Bonacorsi SJ, Knabb RM, Skiles GL, He K. Zhang D, et al. Among authors: he k. Drug Metab Dispos. 2008 Feb;36(2):303-15. doi: 10.1124/dmd.107.018416. Epub 2007 Nov 5. Drug Metab Dispos. 2008. PMID: 17984286

4

Inhibition of MDR3 Activity in Human Hepatocytes by Drugs Associated with Liver Injury.

He K, Cai L, Shi Q, Liu H, Woolf TF. He K, et al. Chem Res Toxicol. 2015 Oct 19;28(10):1987-90. doi: 10.1021/acs.chemrestox.5b00201. Epub 2015 Sep 15. Chem Res Toxicol. 2015. PMID: 26335978

5

Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping.

Gan J, Qu Q, He B, Shyu WC, Rodrigues AD, He K. Gan J, et al. Among authors: he k, he b. Drug Metab Lett. 2008 Aug;2(3):184-9. doi: 10.2174/187231208785425773. Drug Metab Lett. 2008. PMID: 19356091

6

In vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review.

Cheng Y, Woolf TF, Gan J, He K. Cheng Y, et al. Among authors: he k. Chem Biol Interact. 2016 Aug 5;255:23-30. doi: 10.1016/j.cbi.2015.11.029. Epub 2015 Dec 10. Chem Biol Interact. 2016. PMID: 26683212 Review.

7

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse.

Zhang J, He K, Cai L, Chen YC, Yang Y, Shi Q, Woolf TF, Ge W, Guo L, Borlak J, Tong W. Zhang J, et al. Among authors: he k. Chem Biol Interact. 2016 Aug 5;255:45-54. doi: 10.1016/j.cbi.2016.03.019. Epub 2016 Mar 19. Chem Biol Interact. 2016. PMID: 27000539 Free PMC article.

8

The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.

Wong H, Grossman SJ, Bai SA, Diamond S, Wright MR, Grace JE Jr, Qian M, He K, Yeleswaram K, Christ DD. Wong H, et al. Among authors: he k. Drug Metab Dispos. 2004 Dec;32(12):1359-69. doi: 10.1124/dmd.104.000943. Epub 2004 Aug 27. Drug Metab Dispos. 2004. PMID: 15333515

9

In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.

Wang L, Zhang D, Raghavan N, Yao M, Ma L, Frost CE, Maxwell BD, Chen SY, He K, Goosen TC, Humphreys WG, Grossman SJ. Wang L, et al. Among authors: he k. Drug Metab Dispos. 2010 Mar;38(3):448-58. doi: 10.1124/dmd.109.029694. Epub 2009 Nov 25. Drug Metab Dispos. 2010. PMID: 19940026

10

Sulfation of o-demethyl apixaban: enzyme identification and species comparison.

Wang L, Raghavan N, He K, Luettgen JM, Humphreys WG, Knabb RM, Pinto DJ, Zhang D. Wang L, et al. Among authors: he k. Drug Metab Dispos. 2009 Apr;37(4):802-8. doi: 10.1124/dmd.108.025593. Epub 2009 Jan 8. Drug Metab Dispos. 2009. PMID: 19131519

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