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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.
Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PA, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bates GP. Hockly E, et al. Among authors: smith dl. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6. doi: 10.1073/pnas.0437870100. Epub 2003 Feb 7. Proc Natl Acad Sci U S A. 2003. PMID: 12576549 Free PMC article.
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP. Sathasivam K, et al. Among authors: smith dl. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22. Proc Natl Acad Sci U S A. 2013. PMID: 23341618 Free PMC article.
Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.
Mielcarek M, Inuabasi L, Bondulich MK, Muller T, Osborne GF, Franklin SA, Smith DL, Neueder A, Rosinski J, Rattray I, Protti A, Bates GP. Mielcarek M, et al. Among authors: smith dl. PLoS Genet. 2014 Aug 7;10(8):e1004550. doi: 10.1371/journal.pgen.1004550. eCollection 2014 Aug. PLoS Genet. 2014. PMID: 25101683 Free PMC article.
Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.
Bondulich MK, Jolinon N, Osborne GF, Smith EJ, Rattray I, Neueder A, Sathasivam K, Ahmed M, Ali N, Benjamin AC, Chang X, Dick JRT, Ellis M, Franklin SA, Goodwin D, Inuabasi L, Lazell H, Lehar A, Richard-Londt A, Rosinski J, Smith DL, Wood T, Tabrizi SJ, Brandner S, Greensmith L, Howland D, Munoz-Sanjuan I, Lee SJ, Bates GP. Bondulich MK, et al. Among authors: smith dl, smith ej. Sci Rep. 2017 Oct 27;7(1):14275. doi: 10.1038/s41598-017-14290-3. Sci Rep. 2017. PMID: 29079832 Free PMC article.
1,640 results