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Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).
Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S. Challis BG, et al. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. doi: 10.1073/pnas.0306931101. Epub 2004 Mar 15. Proc Natl Acad Sci U S A. 2004. PMID: 15070780 Free PMC article.
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S. Challis BG, et al. Hum Mol Genet. 2002 Aug 15;11(17):1997-2004. doi: 10.1093/hmg/11.17.1997. Hum Mol Genet. 2002. PMID: 12165561
Minireview: human obesity-lessons from monogenic disorders.
O'Rahilly S, Farooqi IS, Yeo GS, Challis BG. O'Rahilly S, et al. Among authors: challis bg. Endocrinology. 2003 Sep;144(9):3757-64. doi: 10.1210/en.2003-0373. Endocrinology. 2003. PMID: 12933645 Review.
Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production.
Coll AP, Fassnacht M, Klammer S, Hahner S, Schulte DM, Piper S, Tung YC, Challis BG, Weinstein Y, Allolio B, O'Rahilly S, Beuschlein F. Coll AP, et al. Among authors: challis bg. J Endocrinol. 2006 Aug;190(2):515-25. doi: 10.1677/joe.1.06749. J Endocrinol. 2006. PMID: 16899584 Free PMC article.
81 results