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Page 1
Synthesis and activity of small molecule GPR40 agonists.
Garrido DM, Corbett DF, Dwornik KA, Goetz AS, Littleton TR, McKeown SC, Mills WY, Smalley TL Jr, Briscoe CP, Peat AJ. Garrido DM, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5. doi: 10.1016/j.bmcl.2006.01.007. Epub 2006 Jan 24. Bioorg Med Chem Lett. 2006. PMID: 16439116
The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
Hertzog DL, Al-Barazanji KA, Bigham EC, Bishop MJ, Britt CS, Carlton DL, Cooper JP, Daniels AJ, Garrido DM, Goetz AS, Grizzle MK, Guo YC, Handlon AL, Ignar DM, Morgan RO, Peat AJ, Tavares FX, Zhou H. Hertzog DL, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7. doi: 10.1016/j.bmcl.2006.07.008. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870432
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Thomson SA, Banker P, Bickett DM, Boucheron JA, Carter HL, Clancy DC, Cooper JP, Dickerson SH, Garrido DM, Nolte RT, Peat AJ, Sheckler LR, Sparks SM, Tavares FX, Wang L, Wang TY, Weiel JE. Thomson SA, et al. Among authors: garrido dm. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1177-82. doi: 10.1016/j.bmcl.2008.12.085. Epub 2008 Dec 25. Bioorg Med Chem Lett. 2009. PMID: 19138846
Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors.
Peat AJ, Boucheron JA, Dickerson SH, Garrido D, Mills W, Peckham J, Preugschat F, Smalley T, Schweiker SL, Wilson JR, Wang TY, Zhou HQ, Thomson SA. Peat AJ, et al. Among authors: garrido d. Bioorg Med Chem Lett. 2004 May 3;14(9):2121-5. doi: 10.1016/j.bmcl.2004.02.036. Bioorg Med Chem Lett. 2004. PMID: 15080992
Novel GSK-3 inhibitors with improved cellular activity.
Peat AJ, Garrido D, Boucheron JA, Schweiker SL, Dickerson SH, Wilson JR, Wang TY, Thomson SA. Peat AJ, et al. Among authors: garrido d. Bioorg Med Chem Lett. 2004 May 3;14(9):2127-30. doi: 10.1016/j.bmcl.2004.02.037. Bioorg Med Chem Lett. 2004. PMID: 15080993
Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3.
Smalley TL Jr, Peat AJ, Boucheron JA, Dickerson S, Garrido D, Preugschat F, Schweiker SL, Thomson SA, Wang TY. Smalley TL Jr, et al. Among authors: garrido d. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2091-4. doi: 10.1016/j.bmcl.2006.01.057. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16460937
241 results