Chen Y - Search Results

1

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.

Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, Sedgwick JD, Cua DJ. Murphy CA, et al. Among authors: chen y. J Exp Med. 2003 Dec 15;198(12):1951-7. doi: 10.1084/jem.20030896. Epub 2003 Dec 8. J Exp Med. 2003. PMID: 14662908 Free PMC article.

2

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.

Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD. Cua DJ, et al. Among authors: chen y. Nature. 2003 Feb 13;421(6924):744-8. doi: 10.1038/nature01355. Nature. 2003. PMID: 12610626

3

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.

Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. Langrish CL, et al. Among authors: chen y. J Exp Med. 2005 Jan 17;201(2):233-40. doi: 10.1084/jem.20041257. J Exp Med. 2005. PMID: 15657292 Free PMC article.

4

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis.

Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ. Chen Y, et al. J Clin Invest. 2006 May;116(5):1317-26. doi: 10.1172/JCI25308. J Clin Invest. 2006. PMID: 16670771 Free PMC article.

5

IL-25 regulates Th17 function in autoimmune inflammation.

Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ. Kleinschek MA, et al. Among authors: chen y. J Exp Med. 2007 Jan 22;204(1):161-70. doi: 10.1084/jem.20061738. Epub 2007 Jan 2. J Exp Med. 2007. PMID: 17200411 Free PMC article.

6

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.

McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ. McGeachy MJ, et al. Among authors: chen y. Nat Immunol. 2007 Dec;8(12):1390-7. doi: 10.1038/ni1539. Epub 2007 Nov 11. Nat Immunol. 2007. PMID: 17994024

7

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.

McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ, Cua DJ. McGeachy MJ, et al. Among authors: chen y. Nat Immunol. 2009 Mar;10(3):314-24. doi: 10.1038/ni.1698. Epub 2009 Feb 1. Nat Immunol. 2009. PMID: 19182808 Free PMC article.

8

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.

Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA. Diveu C, et al. Among authors: chen y. J Immunol. 2009 May 1;182(9):5748-56. doi: 10.4049/jimmunol.0801162. J Immunol. 2009. PMID: 19380822

9

Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.

Chen Y, Haines CJ, Gutcher I, Hochweller K, Blumenschein WM, McClanahan T, Hämmerling G, Li MO, Cua DJ, McGeachy MJ. Chen Y, et al. Immunity. 2011 Mar 25;34(3):409-21. doi: 10.1016/j.immuni.2011.02.011. Immunity. 2011. PMID: 21435588 Free article.

10

The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production.

Tato CM, Joyce-Shaikh B, Banerjee A, Chen Y, Sathe M, Ewald SE, Liu MR, Gorman D, McClanahan TK, Phillips JH, Heyworth PG, Cua DJ. Tato CM, et al. Among authors: chen y. PLoS One. 2012;7(3):e31680. doi: 10.1371/journal.pone.0031680. Epub 2012 Mar 27. PLoS One. 2012. PMID: 22479310 Free PMC article.

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