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Hepatic fibrogenesis requires sympathetic neurotransmitters.
Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, Thomas SA, Diehl AM. Oben JA, et al. Among authors: roskams t. Gut. 2004 Mar;53(3):438-45. doi: 10.1136/gut.2003.026658. Gut. 2004. PMID: 14960531 Free PMC article.
Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice.
Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Li Z, Torbenson M, Thomas SA, Diehl AM. Oben JA, et al. Among authors: roskams t. Biochem Biophys Res Commun. 2003 Aug 22;308(2):284-92. doi: 10.1016/s0006-291x(03)01360-3. Biochem Biophys Res Commun. 2003. PMID: 12901866
Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells.
Sigala B, McKee C, Soeda J, Pazienza V, Morgan M, Lin CI, Selden C, Vander Borght S, Mazzoccoli G, Roskams T, Vinciguerra M, Oben JA. Sigala B, et al. Among authors: roskams t. PLoS One. 2013 Sep 3;8(9):e72928. doi: 10.1371/journal.pone.0072928. eCollection 2013. PLoS One. 2013. PMID: 24019886 Free PMC article.
404 results