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2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
Bendaly J, Zhao S, Neale JR, Metry KJ, Doll MA, States JC, Pierce WM Jr, Hein DW. Bendaly J, et al. Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1503-9. doi: 10.1158/1055-9965.EPI-07-0305. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 17627018 Free PMC article.
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
Metry KJ, Neale JR, Bendaly J, Smith NB, Pierce WM Jr, Hein DW. Metry KJ, et al. Among authors: bendaly j. Drug Metab Dispos. 2009 Nov;37(11):2123-6. doi: 10.1124/dmd.109.029512. Epub 2009 Aug 10. Drug Metab Dispos. 2009. PMID: 19666988 Free PMC article.