Numazawa M - Search Results

1

Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs.

Numazawa M, Watari Y, Yamada K, Umemura N, Handa W. Numazawa M, et al. Steroids. 2003 Aug;68(6):503-13. doi: 10.1016/s0039-128x(03)00089-8. Steroids. 2003. PMID: 12906935

2

Aromatase inhibition by 4 beta,5 beta-epoxides of 16 alpha-hydroxyandrostenedione and its 19-oxygenated analogs, potential precursors of estriol production in the feto-placental unit.

Numazawa M, Yoshimura A, Watari Y, Matsuzaki H. Numazawa M, et al. Biol Pharm Bull. 2002 Dec;25(12):1566-9. doi: 10.1248/bpb.25.1566. Biol Pharm Bull. 2002. PMID: 12499641 Free article.

3

Structure-activity relationships of 3-deoxy androgens as aromatase inhibitors. Synthesis and biochemical studies of 4-substituted 4-ene and 5-ene steroids.

Nagaoka M, Watari Y, Yajima H, Tsukioka K, Muroi Y, Yamada K, Numazawa M. Nagaoka M, et al. Among authors: numazawa m. Steroids. 2003 Aug;68(6):533-42. doi: 10.1016/s0039-128x(03)00085-0. Steroids. 2003. PMID: 12906938

4

Synthesis and biochemical properties of 6-bromoandrostenedione derivatives with a 2,2-dimethyl or 2-methyl group as aromatase inhibitors.

Numazawa M, Handa W, Yamada K. Numazawa M, et al. Biol Pharm Bull. 2004 Nov;27(11):1878-82. doi: 10.1248/bpb.27.1878. Biol Pharm Bull. 2004. PMID: 15516742 Free article.

5

Structure-activity relationships of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors.

Numazawa M, Ando M, Watari Y, Tominaga T, Hayata Y, Yoshimura A. Numazawa M, et al. J Steroid Biochem Mol Biol. 2005 Jun;96(1):51-8. doi: 10.1016/j.jsbmb.2005.01.028. J Steroid Biochem Mol Biol. 2005. PMID: 16039845

6

Structure-activity relationships of 2alpha-substituted androstenedione analogs as aromatase inhibitors and their aromatization reactions.

Numazawa M, Handa W, Hasegawa C, Takahashi M. Numazawa M, et al. J Steroid Biochem Mol Biol. 2005 Dec;97(4):353-9. doi: 10.1016/j.jsbmb.2005.06.029. Epub 2005 Oct 4. J Steroid Biochem Mol Biol. 2005. PMID: 16209922

7

Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates.

Numazawa M, Tominaga T, Watari Y, Tada Y. Numazawa M, et al. Steroids. 2006 May;71(5):371-9. doi: 10.1016/j.steroids.2005.12.004. Epub 2006 Feb 14. Steroids. 2006. PMID: 16476457

8

Gas chromatography-mass spectrometric study of 19-oxygenation of the aromatase inhibitor 19-methylandrostenedione with human placental microsomes.

Numazawa M, Nagaoka M, Handa W, Yamada A. Numazawa M, et al. Biol Pharm Bull. 2006 Jun;29(6):1242-5. doi: 10.1248/bpb.29.1242. Biol Pharm Bull. 2006. PMID: 16755025 Free article.

9

Biochemical aromatization of 2-methyleneandrostenedione: stereochemistry of hydrogen removal at the C-1 position.

Numazawa M, Handa W, Matsuzaki H. Numazawa M, et al. J Steroid Biochem Mol Biol. 2006 Nov;101(4-5):239-45. doi: 10.1016/j.jsbmb.2006.06.026. Epub 2006 Sep 18. J Steroid Biochem Mol Biol. 2006. PMID: 16979892

10

Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.

Numazawa M, Nagaoka M, Handa W, Ogawa Y, Matsuoka S. Numazawa M, et al. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):211-9. doi: 10.1016/j.jsbmb.2007.03.042. Epub 2007 Jun 22. J Steroid Biochem Mol Biol. 2007. PMID: 17656084

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