Fujii N - Search Results

1

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.

Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC. Fujii N, et al. Angew Chem Int Ed Engl. 2003 Jul 21;42(28):3251-3. doi: 10.1002/anie.200351024. Angew Chem Int Ed Engl. 2003. PMID: 12876735 No abstract available.

2

The therapeutic potential of CXCR4 antagonists in the treatment of HIV.

Fujii N, Nakashima H, Tamamura H. Fujii N, et al. Expert Opin Investig Drugs. 2003 Feb;12(2):185-95. doi: 10.1517/13543784.12.2.185. Expert Opin Investig Drugs. 2003. PMID: 12556213 Review.

3

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.

Tamamura H, Hiramatsu K, Kusano aS, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Org Biomol Chem. 2003 Nov 7;1(21):3656-62. doi: 10.1039/b306473p. Org Biomol Chem. 2003. PMID: 14649896

4

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.

Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Org Biomol Chem. 2003 Nov 7;1(21):3663-9. doi: 10.1039/b306613b. Org Biomol Chem. 2003. PMID: 14649897

5

Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides.

Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Org Biomol Chem. 2004 Apr 21;2(8):1255-7. doi: 10.1039/b401485p. Epub 2004 Mar 23. Org Biomol Chem. 2004. PMID: 15064805

6

Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.

Tamamura H, Fujisawa M, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. FEBS Lett. 2004 Jul 2;569(1-3):99-104. doi: 10.1016/j.febslet.2004.05.056. FEBS Lett. 2004. PMID: 15225616 Free article.

7

Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.

Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent JO, Peiper SC, Yamamoto N, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. J Med Chem. 2005 Jan 27;48(2):380-91. doi: 10.1021/jm049429h. J Med Chem. 2005. PMID: 15658852

8

Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

Tamamura H, Araki T, Ueda S, Wang Z, Oishi S, Esaka A, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. J Med Chem. 2005 May 5;48(9):3280-9. doi: 10.1021/jm050009h. J Med Chem. 2005. PMID: 15857134

9

Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.

Ueda S, Oishi S, Wang ZX, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, Peiper SC, Fujii N. Ueda S, et al. Among authors: fujii n. J Med Chem. 2007 Jan 25;50(2):192-8. doi: 10.1021/jm0607350. J Med Chem. 2007. PMID: 17228861

10

Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).

Oishi S, Fujii N. Oishi S, et al. Among authors: fujii n. Org Biomol Chem. 2012 Aug 14;10(30):5720-31. doi: 10.1039/c2ob25107h. Epub 2012 Apr 19. Org Biomol Chem. 2012. PMID: 22517031 Free article. Review.

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