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A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S. Tanaka M, et al. Among authors: jay py. Cold Spring Harb Symp Quant Biol. 2002;67:317-25. doi: 10.1101/sqb.2002.67.317. Cold Spring Harb Symp Quant Biol. 2002. PMID: 12858555 No abstract available.
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.
Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O'Brien TX, Gourdie RG, Berul CI, Izumo S. Jay PY, et al. J Clin Invest. 2004 Apr;113(8):1130-7. doi: 10.1172/JCI19846. J Clin Invest. 2004. PMID: 15085192 Free PMC article.
Function follows form: cardiac conduction system defects in Nkx2-5 mutation.
Jay PY, Harris BS, Buerger A, Rozhitskaya O, Maguire CT, Barbosky LA, McCusty E, Berul CI, O'brien TX, Gourdie RG, Izumo S. Jay PY, et al. Anat Rec A Discov Mol Cell Evol Biol. 2004 Oct;280(2):966-72. doi: 10.1002/ar.a.20102. Anat Rec A Discov Mol Cell Evol Biol. 2004. PMID: 15368343 Free article. Review.
67 results