Curtin NJ - Search Results

1

Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

Calabrese CR, Batey MA, Thomas HD, Durkacz BW, Wang LZ, Kyle S, Skalitzky D, Li J, Zhang C, Boritzki T, Maegley K, Calvert AH, Hostomsky Z, Newell DR, Curtin NJ. Calabrese CR, et al. Among authors: curtin nj. Clin Cancer Res. 2003 Jul;9(7):2711-8. Clin Cancer Res. 2003. PMID: 12855651

2

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.

Curtin NJ, Harris AL, Aherne GW. Curtin NJ, et al. Cancer Res. 1991 May 1;51(9):2346-52. Cancer Res. 1991. PMID: 2015598

3

Modulation of dipyridamole action by alpha 1 acid glycoprotein. Reduced potentiation of quinazoline antifolate (CB3717) cytotoxicity by dipyridamole.

Curtin NJ, Newell DR, Harris AL. Curtin NJ, et al. Biochem Pharmacol. 1989 Oct 1;38(19):3281-8. doi: 10.1016/0006-2952(89)90626-6. Biochem Pharmacol. 1989. PMID: 2818627

4

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.

Boulton S, Pemberton LC, Porteous JK, Curtin NJ, Griffin RJ, Golding BT, Durkacz BW. Boulton S, et al. Among authors: curtin nj. Br J Cancer. 1995 Oct;72(4):849-56. doi: 10.1038/bjc.1995.423. Br J Cancer. 1995. PMID: 7547230 Free PMC article.

5

Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP).

Griffin RJ, Pemberton LC, Rhodes D, Bleasdale C, Bowman K, Calvert AH, Curtin NJ, Durkacz BW, Newell DR, Porteous JK, et al. Griffin RJ, et al. Among authors: curtin nj. Anticancer Drug Des. 1995 Sep;10(6):507-14. Anticancer Drug Des. 1995. PMID: 7575991 No abstract available.

6

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. Griffin RJ, et al. Among authors: curtin nj. Biochimie. 1995;77(6):408-22. doi: 10.1016/0300-9084(96)88154-5. Biochimie. 1995. PMID: 7578423 Review.

7

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).

Arris CE, Bleasdale C, Calvert AH, Curtin NJ, Dalby C, Golding BT, Griffin RJ, Lunn JM, Major GN, Newell DR. Arris CE, et al. Among authors: curtin nj. Anticancer Drug Des. 1994 Oct;9(5):401-8. Anticancer Drug Des. 1994. PMID: 7945724 No abstract available.

8

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Bowman KJ, et al. Among authors: curtin nj. Br J Cancer. 1998 Nov;78(10):1269-77. doi: 10.1038/bjc.1998.670. Br J Cancer. 1998. PMID: 9823965 Free PMC article.

9

Dipyridamole potentiates antipurine antifolate activity in the presence of hypoxanthine in tumor cells but not in normal tissues in vitro.

Marshman E, Newell DR, Calvert AH, Dickinson AM, Patel HR, Campbell FC, Curtin NJ. Marshman E, et al. Among authors: curtin nj. Clin Cancer Res. 1998 Nov;4(11):2895-902. Clin Cancer Res. 1998. PMID: 9829758

10

Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. Griffin RJ, et al. Among authors: curtin nj. J Med Chem. 1998 Dec 17;41(26):5247-56. doi: 10.1021/jm980273t. J Med Chem. 1998. PMID: 9857092

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