Witchel HJ - Search Results

1

Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine.

Ridley JM, Milnes JT, Zhang YH, Witchel HJ, Hancox JC. Ridley JM, et al. Among authors: witchel hj. J Physiol. 2003 Jun 15;549(Pt 3):667-72. doi: 10.1113/jphysiol.2003.043976. Epub 2003 May 9. J Physiol. 2003. PMID: 12740430 Free PMC article.

2

Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents.

Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC. Witchel HJ, et al. FEBS Lett. 2002 Feb 13;512(1-3):59-66. doi: 10.1016/s0014-5793(01)03320-8. FEBS Lett. 2002. PMID: 11852052 Free article.

3

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine.

Paul AA, Witchel HJ, Hancox JC. Paul AA, et al. Among authors: witchel hj. Br J Pharmacol. 2002 Jul;136(5):717-29. doi: 10.1038/sj.bjp.0704784. Br J Pharmacol. 2002. PMID: 12086981 Free PMC article.

4

Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.

Ridley JM, Milnes JT, Benest AV, Masters JD, Witchel HJ, Hancox JC. Ridley JM, et al. Among authors: witchel hj. Biochem Biophys Res Commun. 2003 Jun 27;306(2):388-93. doi: 10.1016/s0006-291x(03)00980-x. Biochem Biophys Res Commun. 2003. PMID: 12804575

5

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.

Milnes JT, Crociani O, Arcangeli A, Hancox JC, Witchel HJ. Milnes JT, et al. Among authors: witchel hj. Br J Pharmacol. 2003 Jul;139(5):887-98. doi: 10.1038/sj.bjp.0705335. Br J Pharmacol. 2003. PMID: 12839862 Free PMC article.

6

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin.

Milnes JT, Dempsey CE, Ridley JM, Crociani O, Arcangeli A, Hancox JC, Witchel HJ. Milnes JT, et al. Among authors: witchel hj. FEBS Lett. 2003 Jul 17;547(1-3):20-6. doi: 10.1016/s0014-5793(03)00662-8. FEBS Lett. 2003. PMID: 12860380 Free article.

7

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.

Witchel HJ, Milnes JT, Mitcheson JS, Hancox JC. Witchel HJ, et al. J Pharmacol Toxicol Methods. 2002 Sep-Oct;48(2):65-80. doi: 10.1016/S1056-8719(03)00041-8. J Pharmacol Toxicol Methods. 2002. PMID: 14565563 Review.

8

Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation.

Yuill KH, Borg JJ, Ridley JM, Milnes JT, Witchel HJ, Paul AA, Kozlowski RZ, Hancox JC. Yuill KH, et al. Among authors: witchel hj. Biochem Biophys Res Commun. 2004 May 28;318(2):556-61. doi: 10.1016/j.bbrc.2004.04.063. Biochem Biophys Res Commun. 2004. PMID: 15120636

9

Lidoflazine is a high affinity blocker of the HERG K(+)channel.

Ridley JM, Dooley PC, Milnes JT, Witchel HJ, Hancox JC. Ridley JM, et al. Among authors: witchel hj. J Mol Cell Cardiol. 2004 May;36(5):701-5. doi: 10.1016/j.yjmcc.2004.02.009. J Mol Cell Cardiol. 2004. PMID: 15135665

10

The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.

Witchel HJ, Dempsey CE, Sessions RB, Perry M, Milnes JT, Hancox JC, Mitcheson JS. Witchel HJ, et al. Mol Pharmacol. 2004 Nov;66(5):1201-12. doi: 10.1124/mol.104.001743. Epub 2004 Aug 12. Mol Pharmacol. 2004. PMID: 15308760

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