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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR Jr, Sacchettini JC, Fidock DA. Kuo MR, et al. Among authors: perozzo r. J Biol Chem. 2003 Jun 6;278(23):20851-9. doi: 10.1074/jbc.M211968200. Epub 2003 Feb 26. J Biol Chem. 2003. PMID: 12606558 Free article.
Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates.
Lack G, Homberger-Zizzari E, Folkers G, Scapozza L, Perozzo R. Lack G, et al. Among authors: perozzo r. J Biol Chem. 2006 Apr 7;281(14):9538-46. doi: 10.1074/jbc.M509119200. Epub 2006 Feb 8. J Biol Chem. 2006. PMID: 16467310 Free article.
In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA.
Slepikas L, Chiriano G, Perozzo R, Tardy S, Kranjc A, Patthey-Vuadens O, Ouertatani-Sakouhi H, Kicka S, Harrison CF, Scrignari T, Perron K, Hilbi H, Soldati T, Cosson P, Tarasevicius E, Scapozza L. Slepikas L, et al. Among authors: perozzo r. J Med Chem. 2016 Dec 22;59(24):10917-10928. doi: 10.1021/acs.jmedchem.5b01620. Epub 2016 Dec 9. J Med Chem. 2016. PMID: 26730986
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
Tasdemir D, Topaloglu B, Perozzo R, Brun R, O'Neill R, Carballeira NM, Zhang X, Tonge PJ, Linden A, Rüedi P. Tasdemir D, et al. Among authors: perozzo r. Bioorg Med Chem. 2007 Nov 1;15(21):6834-45. doi: 10.1016/j.bmc.2007.07.032. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17765547
54 results