Lebrun P - Search Results

1

BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

Cosgrove KE, Antoine MH, Lee AT, Barnes PD, de Tullio P, Clayton P, McCloy R, De Lonlay P, Nihoul-Fékété C, Robert JJ, Saudubray JM, Rahier J, Lindley KJ, Hussain K, Aynsley-Green A, Pirotte B, Lebrun P, Dunne MJ. Cosgrove KE, et al. Among authors: lebrun p. J Clin Endocrinol Metab. 2002 Nov;87(11):4860-8. doi: 10.1210/jc.2002-020439. J Clin Endocrinol Metab. 2002. PMID: 12414839

2

Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets.

Antoine MH, Pirotte B, Hermann M, de Tullio P, Delarge J, Herchuelz A, Lebrun P. Antoine MH, et al. Among authors: lebrun p. Experientia. 1994 Sep 15;50(9):830-2. doi: 10.1007/BF01956464. Experientia. 1994. PMID: 7925849

3

A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+ channels.

Pirotte B, Antoine MH, de Tullio P, Hermann M, Herchuelz A, Delarge J, Lebrun P. Pirotte B, et al. Among authors: lebrun p. Biochem Pharmacol. 1994 Apr 20;47(8):1381-6. doi: 10.1016/0006-2952(94)90337-9. Biochem Pharmacol. 1994. PMID: 8185645

4

Activation of ATP-dependent K+ channels and inhibition of insulin release: effect of BPDZ 62.

Lebrun P, Antoine MH, Ouedraogo R, Kane C, Dunne M, Hermann M, Herchuelz A, Masereel B, Delarge J, de Tullio P, Pirotte B. Lebrun P, et al. J Pharmacol Exp Ther. 1996 Apr;277(1):156-62. J Pharmacol Exp Ther. 1996. PMID: 8613913

5

Verapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells from rats.

Lebrun P, Antoine MH, Ouedraogo R, Pirotte B, Herchuelz A, Cosgrove KE, Kane C, Dunne MJ. Lebrun P, et al. Diabetologia. 1997 Dec;40(12):1403-10. doi: 10.1007/s001250050842. Diabetologia. 1997. PMID: 9447947

6

Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissues.

Becker B, Antoine MH, Nguyen QA, Rigo B, Cosgrove KE, Barnes PD, Dunne MJ, Pirotte B, Lebrun P. Becker B, et al. Among authors: lebrun p. Br J Pharmacol. 2001 Sep;134(2):375-85. doi: 10.1038/sj.bjp.0704266. Br J Pharmacol. 2001. PMID: 11564656 Free PMC article.

7

In vitro and in vivo effects of new insulin releasing agents.

Nguyen QA, Antoine MH, Ouedraogo R, Hermann M, Sergooris J, Pirotte B, Masereel B, Lebrun P. Nguyen QA, et al. Among authors: lebrun p. Biochem Pharmacol. 2002 Feb 1;63(3):515-21. doi: 10.1016/s0006-2952(01)00880-2. Biochem Pharmacol. 2002. PMID: 11853702

8

A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release.

Lebrun P, Arkhammar P, Antoine MH, Nguyen QA, Hansen JB, Pirotte B. Lebrun P, et al. Diabetologia. 2000 Jun;43(6):723-32. doi: 10.1007/s001250051370. Diabetologia. 2000. PMID: 10907118

9

Effect on insulin release of compounds structurally related to the potassium-channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-dioxide ring.

Boverie S, Antoine MH, de Tullio P, Somers F, Becker B, Sebille S, Lebrun P, Pirotte B. Boverie S, et al. Among authors: lebrun p. J Pharm Pharmacol. 2001 Jul;53(7):973-80. doi: 10.1211/0022357011776216. J Pharm Pharmacol. 2001. PMID: 11480549

10

3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.

de Tullio P, Boverie S, Becker B, Antoine MH, Nguyen QA, Francotte P, Counerotte S, Sebille S, Pirotte B, Lebrun P. de Tullio P, et al. Among authors: lebrun p. J Med Chem. 2005 Jul 28;48(15):4990-5000. doi: 10.1021/jm0580050. J Med Chem. 2005. PMID: 16033278

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