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Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.
Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A. Cuadrado A, et al. Among authors: suarez y. J Biol Chem. 2003 Jan 3;278(1):241-50. doi: 10.1074/jbc.M201010200. Epub 2002 Oct 31. J Biol Chem. 2003. PMID: 12414812 Free article.
JNK activation is critical for Aplidin-induced apoptosis.
Cuadrado A, González L, Suárez Y, Martínez T, Muñoz A. Cuadrado A, et al. Among authors: suarez y. Oncogene. 2004 Jun 10;23(27):4673-80. doi: 10.1038/sj.onc.1207636. Oncogene. 2004. PMID: 15122339
Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.
González-Santiago L, Suárez Y, Zarich N, Muñoz-Alonso MJ, Cuadrado A, Martínez T, Goya L, Iradi A, Sáez-Tormo G, Maier JV, Moorthy A, Cato AC, Rojas JM, Muñoz A. González-Santiago L, et al. Among authors: suarez y. Cell Death Differ. 2006 Nov;13(11):1968-81. doi: 10.1038/sj.cdd.4401898. Epub 2006 Mar 17. Cell Death Differ. 2006. PMID: 16543941
Vitamin D regulates the phenotype of human breast cancer cells.
Pendás-Franco N, González-Sancho JM, Suárez Y, Aguilera O, Steinmeyer A, Gamallo C, Berciano MT, Lafarga M, Muñoz A. Pendás-Franco N, et al. Among authors: suarez y. Differentiation. 2007 Mar;75(3):193-207. doi: 10.1111/j.1432-0436.2006.00131.x. Epub 2006 Dec 11. Differentiation. 2007. PMID: 17288543
Proteomic analysis of the resistance to aplidin in human cancer cells.
González-Santiago L, Alfonso P, Suárez Y, Núñez A, García-Fernández LF, Alvarez E, Muñoz A, Casal JI. González-Santiago L, et al. Among authors: suarez y. J Proteome Res. 2007 Apr;6(4):1286-94. doi: 10.1021/pr060430+. Epub 2007 Mar 6. J Proteome Res. 2007. PMID: 17338558
179 results