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CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A.
Jacquemin M, Vantomme V, Buhot C, Lavend'homme R, Burny W, Demotte N, Chaux P, Peerlinck K, Vermylen J, Maillere B, van der Bruggen P, Saint-Remy JM. Jacquemin M, et al. Among authors: vermylen j. Blood. 2003 Feb 15;101(4):1351-8. doi: 10.1182/blood-2002-05-1369. Epub 2002 Oct 17. Blood. 2003. PMID: 12393451 Free article.
Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development.
d'Oiron R, Lavergne JM, Lavend'homme R, Benhida A, Bordet JC, Negrier C, Peerlinck K, Vermylen J, Saint-Remy JM, Jacquemin M. d'Oiron R, et al. Among authors: vermylen j. Blood. 2004 Jan 1;103(1):155-7. doi: 10.1182/blood-2003-04-1321. Epub 2003 Sep 11. Blood. 2004. PMID: 12969981 Free article.
499 results