A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW 2nd.
Liggett SB, et al.
Nat Med. 2008 May;14(5):510-7. doi: 10.1038/nm1750. Epub 2008 Apr 20.
Nat Med. 2008.
PMID: 18425130
Free PMC article.