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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B. Herreman A, et al. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7. doi: 10.1073/pnas.96.21.11872. Proc Natl Acad Sci U S A. 1999. PMID: 10518543 Free PMC article.
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.
Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Nyabi O, et al. Among authors: herreman a. J Biol Chem. 2003 Oct 31;278(44):43430-6. doi: 10.1074/jbc.M306957200. Epub 2003 Jul 28. J Biol Chem. 2003. PMID: 12885769 Free article.
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Dejaegere T, et al. Among authors: herreman a. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9775-80. doi: 10.1073/pnas.0800507105. Epub 2008 Jul 14. Proc Natl Acad Sci U S A. 2008. PMID: 18626010 Free PMC article.
No endogenous A beta production in presenilin-deficient fibroblasts.
Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B. Nyabi O, et al. Among authors: herreman a. Nat Cell Biol. 2002 Jul;4(7):E164; author reply E165-6. doi: 10.1038/ncb0702-e164a. Nat Cell Biol. 2002. PMID: 12105423 No abstract available.
Notch pathway is dispensable for adipocyte specification.
Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Nichols AM, et al. Among authors: herreman a. Genesis. 2004 Sep;40(1):40-4. doi: 10.1002/gene.20061. Genesis. 2004. PMID: 15354292
Role of presenilins in neuronal calcium homeostasis.
Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Zhang H, et al. Among authors: herreman a. J Neurosci. 2010 Jun 23;30(25):8566-80. doi: 10.1523/JNEUROSCI.1554-10.2010. J Neurosci. 2010. PMID: 20573903 Free PMC article.
14 results