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Page 1
Structure of the insulin receptor ectodomain reveals a folded-over conformation.
McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW. McKern NM, et al. Among authors: frenkel mj. Nature. 2006 Sep 14;443(7108):218-21. doi: 10.1038/nature05106. Epub 2006 Sep 6. Nature. 2006. PMID: 16957736
The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Lou M, Garrett TP, McKern NM, Hoyne PA, Epa VC, Bentley JD, Lovrecz GO, Cosgrove LJ, Frenkel MJ, Ward CW. Lou M, et al. Among authors: frenkel mj. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12429-34. doi: 10.1073/pnas.0605395103. Epub 2006 Aug 7. Proc Natl Acad Sci U S A. 2006. PMID: 16894147 Free PMC article.
The three dimensional structure of the type I insulin-like growth factor receptor.
Ward CW, Garrett TP, McKern NM, Lou M, Cosgrove LJ, Sparrow LG, Frenkel MJ, Hoyne PA, Elleman TC, Adams TE, Lovrecz GO, Lawrence LJ, Tulloch PA. Ward CW, et al. Among authors: frenkel mj. Mol Pathol. 2001 Jun;54(3):125-32. doi: 10.1136/mp.54.3.125. Mol Pathol. 2001. PMID: 11376122 Free PMC article. Review.
Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.
Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW. Jagadish MN, et al. Among authors: frenkel mj. Biochem J. 1996 Aug 1;317 ( Pt 3)(Pt 3):945-54. doi: 10.1042/bj3170945. Biochem J. 1996. PMID: 8760387 Free PMC article.
38 results