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1alpha,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1alpha,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells.
Siu-Caldera ML, Clark JW, Santos-Moore A, Peleg S, Liu YY, Uskoković MR, Sharma S, Reddy GS. Siu-Caldera ML, et al. Among authors: peleg s. J Steroid Biochem Mol Biol. 1996 Dec;59(5-6):405-12. doi: 10.1016/s0960-0760(96)00134-3. J Steroid Biochem Mol Biol. 1996. PMID: 9010346
Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity.
Siu-Caldera ML, Sekimoto H, Peleg S, Nguyen C, Kissmeyer AM, Binderup L, Weiskopf A, Vouros P, Uskoković MR, Reddy GS. Siu-Caldera ML, et al. Among authors: peleg s. J Steroid Biochem Mol Biol. 1999 Dec 15;71(3-4):111-21. doi: 10.1016/s0960-0760(99)00130-2. J Steroid Biochem Mol Biol. 1999. PMID: 10659699
Synthesis and biological activities of the two C(23) epimers of 1alpha,23,25-trihydroxy-24-oxo-19-nor-vitamin D(3): novel analogs of 1alpha,23(S),25-trihydroxy-24-oxo-vitamin D(3), a natural metabolite of 1alpha,25-dihydroxyvitamin D(3).
Lee NE, Williard PG, Brown AJ, Campbell MJ, Koeffler HP, Peleg S, Rao DS, Reddy GS. Lee NE, et al. Among authors: peleg s. Steroids. 2000 May;65(5):252-65. doi: 10.1016/s0039-128x(99)00110-5. Steroids. 2000. PMID: 10751637
Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.
Posner GH, Crawford KR, Yang HW, Kahraman M, Jeon HB, Li H, Lee JK, Suh BC, Hatcher MA, Labonte T, Usera A, Dolan PM, Kensler TW, Peleg S, Jones G, Zhang A, Korczak B, Saha U, Chuang SS. Posner GH, et al. Among authors: peleg s. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):5-12. doi: 10.1016/j.jsbmb.2004.03.044. J Steroid Biochem Mol Biol. 2004. PMID: 15225738
188 results