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Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency.
Zakas PM, Cunningham SC, Doherty A, van Dijk EB, Ibraheim R, Yu S, Mekonnen BD, Lang B, English EJ, Sun G, Duncan MC, Benczkowski MS, Altshuler RC, Singh MJ, Kibbler ES, Tonga GY, Wang ZJ, Wang ZJ, Li G, An D, Rottman JB, Bhavsar Y, Purcell C, Jain R, Alberry R, Roquet N, Fu Y, Citorik RJ, Rubens JR, Holmes MC, Cotta-Ramusino C, Querbes W, Alexander IE, Salomon WE. Zakas PM, et al. Among authors: cunningham sc. Mol Ther. 2024 Oct 2;32(10):3356-3371. doi: 10.1016/j.ymthe.2024.06.021. Epub 2024 Jul 8. Mol Ther. 2024. PMID: 38981468
Predictors of In-Hospital Mortality Following Pancreatectomy.
Axentiev A, Shmelev A, Cunningham SC. Axentiev A, et al. Among authors: cunningham sc. Cureus. 2023 Sep 23;15(9):e45830. doi: 10.7759/cureus.45830. eCollection 2023 Sep. Cureus. 2023. PMID: 37881394 Free PMC article.
Recapitulation of Skewed X-Inactivation in Female Ornithine Transcarbamylase-Deficient Primary Human Hepatocytes in the FRG Mouse: A Novel System for Developing Epigenetic Therapies.
Cunningham SC, van Dijk EB, Zhu E, Sugden M, Mandwie M, Siew S, Devanapalli B, Tolun AA, Klein A, Wilson L, Aryamanesh N, Gissen P, Baruteau J, Bhattacharya K, Alexander IE. Cunningham SC, et al. Hum Gene Ther. 2023 Sep;34(17-18):917-926. doi: 10.1089/hum.2023.011. Epub 2023 Sep 11. Hum Gene Ther. 2023. PMID: 37350098
A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. Among authors: cunningham sc. Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005. Epub 2023 Apr 27. Mol Cell. 2023. PMID: 37116496 Free PMC article.
A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. Among authors: cunningham sc. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528512. doi: 10.1101/2023.02.14.528512. bioRxiv. 2023. Update in: Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005 PMID: 36824822 Free PMC article. Updated. Preprint.
Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice.
Deplazes S, Schlegel A, Song Z, Allegri G, Rimann N, Scherer T, Willimann M, Opitz L, Cunningham SC, Alexander IE, Kipar A, Häberle J, Thöny B, Grisch-Chan HM. Deplazes S, et al. Among authors: cunningham sc. Mol Ther Methods Clin Dev. 2022 Oct 10;27:352-367. doi: 10.1016/j.omtm.2022.10.006. eCollection 2022 Dec 8. Mol Ther Methods Clin Dev. 2022. PMID: 36381301 Free PMC article.
171 results