Geary RS - Search Results

1

Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer.

Mani S, Rudin CM, Kunkel K, Holmlund JT, Geary RS, Kindler HL, Dorr FA, Ratain MJ. Mani S, et al. Among authors: geary rs. Clin Cancer Res. 2002 Apr;8(4):1042-8. Clin Cancer Res. 2002. PMID: 11948111 Clinical Trial.

2

A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.

Villalona-Calero MA, Ritch P, Figueroa JA, Otterson GA, Belt R, Dow E, George S, Leonardo J, McCachren S, Miller GL, Modiano M, Valdivieso M, Geary R, Oliver JW, Holmlund J. Villalona-Calero MA, et al. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6086-93. doi: 10.1158/1078-0432.CCR-04-0779. Clin Cancer Res. 2004. PMID: 15447994 Clinical Trial.

3

A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer.

Adjei AA, Dy GK, Erlichman C, Reid JM, Sloan JA, Pitot HC, Alberts SR, Goldberg RM, Hanson LJ, Atherton PJ, Watanabe T, Geary RS, Holmlund J, Dorr FA. Adjei AA, et al. Among authors: geary rs. Clin Cancer Res. 2003 Jan;9(1):115-23. Clin Cancer Res. 2003. PMID: 12538459 Clinical Trial.

4

A phase I trial of aprinocarsen (ISIS 3521/LY900003), an antisense inhibitor of protein kinase C-alpha administered as a 24-hour weekly infusion schedule in patients with advanced cancer.

Advani R, Lum BL, Fisher GA, Halsey J, Geary RS, Holmlund JT, Kwoh TJ, Dorr FA, Sikic BI. Advani R, et al. Among authors: geary rs. Invest New Drugs. 2005 Oct;23(5):467-77. doi: 10.1007/s10637-005-2906-0. Invest New Drugs. 2005. PMID: 16133798 Clinical Trial.

5

Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer.

Nemunaitis J, Holmlund JT, Kraynak M, Richards D, Bruce J, Ognoskie N, Kwoh TJ, Geary R, Dorr A, Von Hoff D, Eckhardt SG. Nemunaitis J, et al. J Clin Oncol. 1999 Nov;17(11):3586-95. doi: 10.1200/JCO.1999.17.11.3586. J Clin Oncol. 1999. PMID: 10550158 Clinical Trial.

6

Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.

Rudin CM, Holmlund J, Fleming GF, Mani S, Stadler WM, Schumm P, Monia BP, Johnston JF, Geary R, Yu RZ, Kwoh TJ, Dorr FA, Ratain MJ. Rudin CM, et al. Clin Cancer Res. 2001 May;7(5):1214-20. Clin Cancer Res. 2001. PMID: 11350886 Clinical Trial.

7

Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer.

Yuen AR, Halsey J, Fisher GA, Holmlund JT, Geary RS, Kwoh TJ, Dorr A, Sikic BI. Yuen AR, et al. Among authors: geary rs. Clin Cancer Res. 1999 Nov;5(11):3357-63. Clin Cancer Res. 1999. PMID: 10589745 Clinical Trial.

8

A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer.

Cunningham CC, Holmlund JT, Schiller JH, Geary RS, Kwoh TJ, Dorr A, Nemunaitis J. Cunningham CC, et al. Among authors: geary rs. Clin Cancer Res. 2000 May;6(5):1626-31. Clin Cancer Res. 2000. PMID: 10815879 Clinical Trial.

9

Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha.

Sewell KL, Geary RS, Baker BF, Glover JM, Mant TG, Yu RZ, Tami JA, Dorr FA. Sewell KL, et al. Among authors: geary rs. J Pharmacol Exp Ther. 2002 Dec;303(3):1334-43. doi: 10.1124/jpet.102.036749. J Pharmacol Exp Ther. 2002. PMID: 12438559 Clinical Trial.

10

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.

Cunningham CC, Holmlund JT, Geary RS, Kwoh TJ, Dorr A, Johnston JF, Monia B, Nemunaitis J. Cunningham CC, et al. Among authors: geary rs. Cancer. 2001 Sep 1;92(5):1265-71. doi: 10.1002/1097-0142(20010901)92:5<1265::aid-cncr1447>3.0.co;2-5. Cancer. 2001. PMID: 11571742 Clinical Trial.

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