Klunk WE - Search Results

1

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. Mathis CA, et al. Among authors: klunk we. Bioorg Med Chem Lett. 2002 Feb 11;12(3):295-8. doi: 10.1016/s0960-894x(01)00734-x. Bioorg Med Chem Lett. 2002. PMID: 11814781

2

Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites.

Klunk WE, Debnath ML, McClure RJ, Pettegrew JW. Klunk WE, et al. Life Sci. 1995;56(26):2377-83. doi: 10.1016/0024-3205(95)00231-t. Life Sci. 1995. PMID: 7791524

3

Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease.

Klunk WE, Debnath ML, Pettegrew JW. Klunk WE, et al. Neurobiol Aging. 1994 Nov-Dec;15(6):691-8. doi: 10.1016/0197-4580(94)90050-7. Neurobiol Aging. 1994. PMID: 7891823

4

Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe.

Klunk WE, Debnath ML, Pettegrew JW. Klunk WE, et al. Neurobiol Aging. 1995 Jul-Aug;16(4):541-8. doi: 10.1016/0197-4580(95)00058-m. Neurobiol Aging. 1995. PMID: 8544903

5

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells.

Klunk WE, Debnath ML, Koros AM, Pettegrew JW. Klunk WE, et al. Life Sci. 1998;63(20):1807-14. doi: 10.1016/s0024-3205(98)00454-8. Life Sci. 1998. PMID: 9820124

6

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

Link CD, Johnson CJ, Fonte V, Paupard M, Hall DH, Styren S, Mathis CA, Klunk WE. Link CD, et al. Among authors: klunk we. Neurobiol Aging. 2001 Mar-Apr;22(2):217-26. doi: 10.1016/s0197-4580(00)00237-2. Neurobiol Aging. 2001. PMID: 11182471

7

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA. Klunk WE, et al. Life Sci. 2001 Aug 17;69(13):1471-84. doi: 10.1016/s0024-3205(01)01232-2. Life Sci. 2001. PMID: 11554609

8

Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease.

Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, Mathis CA. Wang Y, et al. Among authors: klunk we. J Mol Neurosci. 2002 Aug-Oct;19(1-2):11-6. doi: 10.1007/s12031-002-0004-8. J Mol Neurosci. 2002. PMID: 12212766

9

Imaging amyloid-beta deposits in vivo.

Bacskai BJ, Klunk WE, Mathis CA, Hyman BT. Bacskai BJ, et al. Among authors: klunk we. J Cereb Blood Flow Metab. 2002 Sep;22(9):1035-41. doi: 10.1097/00004647-200209000-00001. J Cereb Blood Flow Metab. 2002. PMID: 12218409 Review.

10

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.

Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Klunk WE, et al. J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805. doi: 10.1093/jnen/61.9.797. J Neuropathol Exp Neurol. 2002. PMID: 12230326

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