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165 results

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Page 1
Synthesis and biological activity of macrocyclic taxane analogues.
Tarrant JG, Cook D, Fairchild C, Kadow JF, Long BH, Rose WC, Vyas D. Tarrant JG, et al. Among authors: rose wc. Bioorg Med Chem Lett. 2004 May 17;14(10):2555-8. doi: 10.1016/j.bmcl.2004.02.086. Bioorg Med Chem Lett. 2004. PMID: 15109650
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
Saulnier MG, Balasubramanian BN, Long BH, Frennesson DB, Ruediger E, Zimmermann K, Eummer JT, St Laurent DR, Stoffan KM, Naidu BN, Mahler M, Beaulieu F, Bachand C, Lee FY, Fairchild CR, Stadnick LK, Rose WC, Solomon C, Wong H, Martel A, Wright JJ, Kramer R, Langley DR, Vyas DM. Saulnier MG, et al. Among authors: rose wc. J Med Chem. 2005 Apr 7;48(7):2258-61. doi: 10.1021/jm049090z. J Med Chem. 2005. PMID: 15801816
The discovery of BMS-275183: an orally efficacious novel taxane.
Mastalerz H, Cook D, Fairchild CR, Hansel S, Johnson W, Kadow JF, Long BH, Rose WC, Tarrant J, Wu MJ, Xue MQ, Zhang G, Zoeckler M, Vyas DM. Mastalerz H, et al. Among authors: rose wc. Bioorg Med Chem. 2003 Oct 1;11(20):4315-23. doi: 10.1016/s0968-0896(03)00495-4. Bioorg Med Chem. 2003. PMID: 13129567
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
Balasubramanian BN, St Laurent DR, Saulnier MG, Long BH, Bachand C, Beaulieu F, Clarke W, Deshpande M, Eummer J, Fairchild CR, Frennesson DB, Kramer R, Lee FY, Mahler M, Martel A, Naidu BN, Rose WC, Russell J, Ruediger E, Solomon C, Stoffan KM, Wong H, Wright JJ, Zimmermann K, Vyas DM. Balasubramanian BN, et al. Among authors: rose wc. J Med Chem. 2004 Mar 25;47(7):1609-12. doi: 10.1021/jm034197s. J Med Chem. 2004. PMID: 15027851
E-ring desoxy analogues of etoposide.
Saulnier MG, Vyas DM, Langley DR, Doyle TW, Rose WC, Crosswell AR, Long BH. Saulnier MG, et al. Among authors: rose wc. J Med Chem. 1989 Jul;32(7):1418-20. doi: 10.1021/jm00127a002. J Med Chem. 1989. PMID: 2738876 No abstract available.
Synthesis and biological activity of A-nor-paclitaxel analogues.
Chordia MD, Kingston DG, Hamel E, Lin CM, Long BH, Fairchild CA, Johnston KA, Rose WC. Chordia MD, et al. Among authors: rose wc. Bioorg Med Chem. 1997 May;5(5):941-7. doi: 10.1016/s0968-0896(97)00035-7. Bioorg Med Chem. 1997. PMID: 9208103
165 results