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A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families.
Athan ES, Williamson J, Ciappa A, Santana V, Romas SN, Lee JH, Rondon H, Lantigua RA, Medrano M, Torres M, Arawaka S, Rogaeva E, Song YQ, Sato C, Kawarai T, Fafel KC, Boss MA, Seltzer WK, Stern Y, St George-Hyslop P, Tycko B, Mayeux R. Athan ES, et al. Among authors: arawaka s. JAMA. 2001 Nov 14;286(18):2257-63. doi: 10.1001/jama.286.18.2257. JAMA. 2001. PMID: 11710891
Presenilin structure, function and role in Alzheimer disease.
Fraser PE, Yang DS, Yu G, Lévesque L, Nishimura M, Arawaka S, Serpell LC, Rogaeva E, St George-Hyslop P. Fraser PE, et al. Among authors: arawaka s. Biochim Biophys Acta. 2000 Jul 26;1502(1):1-15. doi: 10.1016/s0925-4439(00)00028-4. Biochim Biophys Acta. 2000. PMID: 10899427 Free article. Review.
Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans.
Zhang DM, Levitan D, Yu G, Nishimura M, Chen F, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Liang Y, Holmes E, Milman P, Sato C, Zhang L, St George-Hyslop P. Zhang DM, et al. Among authors: arawaka s. Neuroreport. 2000 Sep 28;11(14):3227-30. doi: 10.1097/00001756-200009280-00035. Neuroreport. 2000. PMID: 11043553
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, George-Hyslop PS. Yu G, et al. Among authors: arawaka s. J Biol Chem. 2000 Sep 1;275(35):27348-53. doi: 10.1074/jbc.M002982200. J Biol Chem. 2000. PMID: 10856299 Free article.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Yu G, et al. Among authors: arawaka s. Nature. 2000 Sep 7;407(6800):48-54. doi: 10.1038/35024009. Nature. 2000. PMID: 10993067
Nicastrin binds to membrane-tethered Notch.
Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser PE, St George-Hyslop PH. Chen F, et al. Among authors: arawaka s. Nat Cell Biol. 2001 Aug;3(8):751-4. doi: 10.1038/35087069. Nat Cell Biol. 2001. PMID: 11483961
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Chen F, et al. Among authors: arawaka s. J Biol Chem. 2003 May 30;278(22):19974-9. doi: 10.1074/jbc.M210049200. Epub 2003 Mar 18. J Biol Chem. 2003. PMID: 12646573 Free article.
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, Fraser PE. Yang DS, et al. Among authors: arawaka s. J Biol Chem. 2002 Aug 2;277(31):28135-42. doi: 10.1074/jbc.M110871200. Epub 2002 May 24. J Biol Chem. 2002. PMID: 12032140 Free article.
87 results