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The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
Ochaion A, Bar-Yehuda S, Cohen S, Amital H, Jacobson KA, Joshi BV, Gao ZG, Barer F, Patoka R, Del Valle L, Perez-Liz G, Fishman P. Ochaion A, et al. Among authors: gao zg. Biochem Pharmacol. 2008 Aug 15;76(4):482-94. doi: 10.1016/j.bcp.2008.05.032. Epub 2008 Jun 17. Biochem Pharmacol. 2008. PMID: 18602896 Free PMC article.
Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity.
Tosh DK, Pavan M, Clark AA, Lammers J, Villano S, Marri S, Sgambellone S, Choi S, Lee J, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Levitan IM, Chen E, Liu N, Demby T, Gavrilova O, Gao ZG, Lucarini L, McCorvy JD, Jacobson KA. Tosh DK, et al. Among authors: gao zg. J Med Chem. 2024 Nov 26. doi: 10.1021/acs.jmedchem.4c02174. Online ahead of print. J Med Chem. 2024. PMID: 39589936
339 results