Zervos AS - Search Results

1

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.

Hegde R, Srinivasula SM, Zhang Z, Wassell R, Mukattash R, Cilenti L, DuBois G, Lazebnik Y, Zervos AS, Fernandes-Alnemri T, Alnemri ES. Hegde R, et al. Among authors: zervos as. J Biol Chem. 2002 Jan 4;277(1):432-8. doi: 10.1074/jbc.M109721200. Epub 2001 Oct 17. J Biol Chem. 2002. PMID: 11606597 Free article.

2

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

Cilenti L, Lee Y, Hess S, Srinivasula S, Park KM, Junqueira D, Davis H, Bonventre JV, Alnemri ES, Zervos AS. Cilenti L, et al. Among authors: zervos as. J Biol Chem. 2003 Mar 28;278(13):11489-94. doi: 10.1074/jbc.M212819200. Epub 2003 Jan 15. J Biol Chem. 2003. PMID: 12529364 Free article.

3

The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.

Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, Dubois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Gupta S, et al. Among authors: zervos as. J Biol Chem. 2004 Oct 29;279(44):45844-54. doi: 10.1074/jbc.M404940200. Epub 2004 Aug 4. J Biol Chem. 2004. PMID: 15294909 Free article.

4

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.

Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, Zervos AS. Cilenti L, et al. Among authors: zervos as. J Biol Chem. 2004 Nov 26;279(48):50295-301. doi: 10.1074/jbc.M406006200. Epub 2004 Sep 15. J Biol Chem. 2004. PMID: 15371414 Free article.

5

Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.

Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL. Liu HR, et al. Among authors: zervos as. Circulation. 2005 Jan 4;111(1):90-6. doi: 10.1161/01.CIR.0000151613.90994.17. Epub 2004 Dec 20. Circulation. 2005. PMID: 15611365

6

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.

Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS. Cilenti L, et al. Among authors: zervos as. Biochim Biophys Acta. 2014 Jul;1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5. Biochim Biophys Acta. 2014. PMID: 24709290 Free article.

7

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.

Kang S, Louboutin JP, Datta P, Landel CP, Martinez D, Zervos AS, Strayer DS, Fernandes-Alnemri T, Alnemri ES. Kang S, et al. Among authors: zervos as. Cell Death Differ. 2013 Feb;20(2):259-69. doi: 10.1038/cdd.2012.117. Epub 2012 Sep 14. Cell Death Differ. 2013. PMID: 22976834 Free PMC article.

8

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.

Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F. Trencia A, et al. Among authors: zervos as. J Biol Chem. 2004 Nov 5;279(45):46566-72. doi: 10.1074/jbc.M406317200. Epub 2004 Aug 24. J Biol Chem. 2004. PMID: 15328349 Free article.

9

Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.

Cilenti L, Kyriazis GA, Soundarapandian MM, Stratico V, Yerkes A, Park KM, Sheridan AM, Alnemri ES, Bonventre JV, Zervos AS. Cilenti L, et al. Among authors: zervos as. Am J Physiol Renal Physiol. 2005 Feb;288(2):F371-9. doi: 10.1152/ajprenal.00154.2004. Epub 2004 Sep 28. Am J Physiol Renal Physiol. 2005. PMID: 15454391 Free article.

10

THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS. Balakrishnan MP, et al. Among authors: zervos as. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H643-53. doi: 10.1152/ajpheart.00234.2009. Epub 2009 Jun 5. Am J Physiol Heart Circ Physiol. 2009. PMID: 19502560 Free PMC article.

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