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Quinazolines as cyclin dependent kinase inhibitors.
Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP. Sielecki TM, et al. Among authors: chen h. Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60. doi: 10.1016/s0960-894x(01)00185-8. Bioorg Med Chem Lett. 2001. PMID: 11354366
Characterization of novel glutathione adducts of a non-nucleoside reverse transcriptase inhibitor, (S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3, 4-dihydro-2(1H)-quinazolinone (DPC 961), in rats. Possible formation of an oxirene metabolic intermediate from a disubstituted alkyne.
Mutlib A, Chen H, Shockcor J, Espina R, Chen S, Cao K, Du A, Nemeth G, Prakash S, Gan LS. Mutlib A, et al. Among authors: chen s, chen h. Chem Res Toxicol. 2000 Aug;13(8):775-84. doi: 10.1021/tx000029g. Chem Res Toxicol. 2000. PMID: 10956066
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