Geary R - Search Results

1

Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.

Rudin CM, Holmlund J, Fleming GF, Mani S, Stadler WM, Schumm P, Monia BP, Johnston JF, Geary R, Yu RZ, Kwoh TJ, Dorr FA, Ratain MJ. Rudin CM, et al. Among authors: geary r. Clin Cancer Res. 2001 May;7(5):1214-20. Clin Cancer Res. 2001. PMID: 11350886 Clinical Trial.

2

Preclinical evaluation of the effects of a novel antisense compound targeting C-raf kinase in mice and monkeys.

Monteith DK, Geary RS, Leeds JM, Johnston J, Monia BP, Levin AA. Monteith DK, et al. Among authors: geary rs. Toxicol Sci. 1998 Dec;46(2):365-75. doi: 10.1006/toxs.1998.2527. Toxicol Sci. 1998. PMID: 10048140

3

Pharmacokinetics and tissue disposition in monkeys of an antisense oligonucleotide inhibitor of Ha-ras encapsulated in stealth liposomes.

Yu RZ, Geary RS, Leeds JM, Watanabe T, Fitchett JR, Matson JE, Mehta R, Hardee GR, Templin MV, Huang K, Newman MS, Quinn Y, Uster P, Zhu G, Working PK, Horner M, Nelson J, Levin AA. Yu RZ, et al. Among authors: geary rs. Pharm Res. 1999 Aug;16(8):1309-15. doi: 10.1023/a:1014822219133. Pharm Res. 1999. PMID: 10468036

4

Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer.

Nemunaitis J, Holmlund JT, Kraynak M, Richards D, Bruce J, Ognoskie N, Kwoh TJ, Geary R, Dorr A, Von Hoff D, Eckhardt SG. Nemunaitis J, et al. Among authors: geary r. J Clin Oncol. 1999 Nov;17(11):3586-95. doi: 10.1200/JCO.1999.17.11.3586. J Clin Oncol. 1999. PMID: 10550158 Clinical Trial.

5

Phase I study of an antisense oligonucleotide to protein kinase C-alpha (ISIS 3521/CGP 64128A) in patients with cancer.

Yuen AR, Halsey J, Fisher GA, Holmlund JT, Geary RS, Kwoh TJ, Dorr A, Sikic BI. Yuen AR, et al. Among authors: geary rs. Clin Cancer Res. 1999 Nov;5(11):3357-63. Clin Cancer Res. 1999. PMID: 10589745 Clinical Trial.

6

A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer.

Cunningham CC, Holmlund JT, Schiller JH, Geary RS, Kwoh TJ, Dorr A, Nemunaitis J. Cunningham CC, et al. Among authors: geary rs. Clin Cancer Res. 2000 May;6(5):1626-31. Clin Cancer Res. 2000. PMID: 10815879 Clinical Trial.

7

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

Yu RZ, Zhang H, Geary RS, Graham M, Masarjian L, Lemonidis K, Crooke R, Dean NM, Levin AA. Yu RZ, et al. Among authors: geary rs. J Pharmacol Exp Ther. 2001 Feb;296(2):388-95. J Pharmacol Exp Ther. 2001. PMID: 11160622

8

Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey.

Yu RZ, Geary RS, Leeds JM, Watanabe T, Moore M, Fitchett J, Matson J, Burckin T, Templin MV, Levin AA. Yu RZ, et al. Among authors: geary rs. J Pharm Sci. 2001 Feb;90(2):182-93. doi: 10.1002/1520-6017(200102)90:2<182::aid-jps9>3.0.co;2-f. J Pharm Sci. 2001. PMID: 11169535

9

Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides.

Geary RS, Yu RZ, Levin AA. Geary RS, et al. Curr Opin Investig Drugs. 2001 Apr;2(4):562-73. Curr Opin Investig Drugs. 2001. PMID: 11566019

10

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.

Cunningham CC, Holmlund JT, Geary RS, Kwoh TJ, Dorr A, Johnston JF, Monia B, Nemunaitis J. Cunningham CC, et al. Among authors: geary rs. Cancer. 2001 Sep 1;92(5):1265-71. doi: 10.1002/1097-0142(20010901)92:5<1265::aid-cncr1447>3.0.co;2-5. Cancer. 2001. PMID: 11571742 Clinical Trial.

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