Gowen M - Search Results

1

Novel bone antiresorptive agents that selectively inhibit the osteoclast V-H+-ATPase.

Farina C, Gagliardi S, Nadler G, Morvan M, Parini C, Belfiore P, Visentin L, Gowen M. Farina C, et al. Among authors: gowen m. Farmaco. 2001 Jan-Feb;56(1-2):113-6. doi: 10.1016/s0014-827x(01)01013-8. Farmaco. 2001. PMID: 11347950 Review.

2

5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.

Gagliardi S, Nadler G, Consolandi E, Parini C, Morvan M, Legave MN, Belfiore P, Zocchetti A, Clarke GD, James I, Nambi P, Gowen M, Farina C. Gagliardi S, et al. Among authors: gowen m. J Med Chem. 1998 May 7;41(10):1568-73. doi: 10.1021/jm9800144. J Med Chem. 1998. PMID: 9572882

3

A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats.

Visentin L, Dodds RA, Valente M, Misiano P, Bradbeer JN, Oneta S, Liang X, Gowen M, Farina C. Visentin L, et al. Among authors: gowen m. J Clin Invest. 2000 Jul;106(2):309-18. doi: 10.1172/JCI6145. J Clin Invest. 2000. PMID: 10903347 Free PMC article.

4

Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.

James IE, Lark MW, Zembryki D, Lee-Rykaczewski EV, Hwang SM, Tomaszek TA, Belfiore P, Gowen M. James IE, et al. Among authors: gowen m. J Bone Miner Res. 1999 Sep;14(9):1562-9. doi: 10.1359/jbmr.1999.14.9.1562. J Bone Miner Res. 1999. PMID: 10469285 Free article.

5

Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.

James IE, Marquis RW, Blake SM, Hwang SM, Gress CJ, Ru Y, Zembryki D, Yamashita DS, McQueney MS, Tomaszek TA, Oh HJ, Gowen M, Veber DF, Lark MW. James IE, et al. Among authors: gowen m. J Biol Chem. 2001 Apr 13;276(15):11507-11. doi: 10.1074/jbc.M010684200. Epub 2001 Jan 8. J Biol Chem. 2001. PMID: 11148212 Free article.

6

Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.

Lark MW, Stroup GB, Dodds RA, Kapadia R, Hoffman SJ, Hwang SM, James IE, Lechowska B, Liang X, Rieman DJ, Salyers KL, Ward K, Smith BR, Miller WH, Huffman WF, Gowen M. Lark MW, et al. Among authors: gowen m. J Bone Miner Res. 2001 Feb;16(2):319-27. doi: 10.1359/jbmr.2001.16.2.319. J Bone Miner Res. 2001. PMID: 11204432 Free article.

7

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.

Lark MW, Stroup GB, James IE, Dodds RA, Hwang SM, Blake SM, Lechowska BA, Hoffman SJ, Smith BR, Kapadia R, Liang X, Erhard K, Ru Y, Dong X, Marquis RW, Veber D, Gowen M. Lark MW, et al. Among authors: gowen m. Bone. 2002 May;30(5):746-53. doi: 10.1016/s8756-3282(02)00675-0. Bone. 2002. PMID: 11996914

8

Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.

Stroup GB, Lark MW, Veber DF, Bhattacharyya A, Blake S, Dare LC, Erhard KF, Hoffman SJ, James IE, Marquis RW, Ru Y, Vasko-Moser JA, Smith BR, Tomaszek T, Gowen M. Stroup GB, et al. Among authors: gowen m. J Bone Miner Res. 2001 Oct;16(10):1739-46. doi: 10.1359/jbmr.2001.16.10.1739. J Bone Miner Res. 2001. PMID: 11585335 Free article.

9

Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.

Votta BJ, Levy MA, Badger A, Bradbeer J, Dodds RA, James IE, Thompson S, Bossard MJ, Carr T, Connor JR, Tomaszek TA, Szewczuk L, Drake FH, Veber DF, Gowen M. Votta BJ, et al. Among authors: gowen m. J Bone Miner Res. 1997 Sep;12(9):1396-406. doi: 10.1359/jbmr.1997.12.9.1396. J Bone Miner Res. 1997. PMID: 9286755 Free article.

10

Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.

Lark MW, Stroup GB, Hwang SM, James IE, Rieman DJ, Drake FH, Bradbeer JN, Mathur A, Erhard KF, Newlander KA, Ross ST, Salyers KL, Smith BR, Miller WH, Huffman WF, Gowen M. Lark MW, et al. Among authors: gowen m. J Pharmacol Exp Ther. 1999 Nov;291(2):612-7. J Pharmacol Exp Ther. 1999. PMID: 10525079

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