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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA. Fisher JE, et al. Among authors: hughes de. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. doi: 10.1073/pnas.96.1.133. Proc Natl Acad Sci U S A. 1999. PMID: 9874784 Free PMC article.
Immune cells and bone resorption.
Gowen M, MacDonald BR, Hughes DE, Skjodt H, Russell RG. Gowen M, et al. Among authors: hughes de. Adv Exp Med Biol. 1986;208:261-73. doi: 10.1007/978-1-4684-5206-8_33. Adv Exp Med Biol. 1986. PMID: 3105268 Review. No abstract available.
198 results