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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, Holmes E, Liang Y, Kawarai T, Jo E, Supala A, Rogaeva E, Xu DM, Janus C, Levesque L, Bi Q, Duthie M, Rozmahel R, Mattila K, Lannfelt L, Westaway D, Mount HT, Woodgett J, St George-Hyslop P, et al. Nishimura M, et al. Among authors: duthie m. Nat Med. 1999 Feb;5(2):164-9. doi: 10.1038/5526. Nat Med. 1999. PMID: 9930863
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.
Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P. Levesque G, et al. Among authors: duthie m. J Neurochem. 1999 Mar;72(3):999-1008. doi: 10.1046/j.1471-4159.1999.0720999.x. J Neurochem. 1999. PMID: 10037471 Free article.
Topological determinants of internal transmembrane segments in P-glycoprotein sequences.
Zhang JT, Lee CH, Duthie M, Ling V. Zhang JT, et al. Among authors: duthie m. J Biol Chem. 1995 Jan 27;270(4):1742-6. doi: 10.1074/jbc.270.4.1742. J Biol Chem. 1995. PMID: 7829509 Free article.
Previously, we have used a coupled cell-free translation/translocation system to investigate the membrane orientation of Pgp sequences and have made the unexpected observation that predicted transmembrane (TM) segments from both the NH2-terminal and COOH-terminal halves inserted …
Previously, we have used a coupled cell-free translation/translocation system to investigate the membrane orientation of Pgp sequences and h …
180 results