Rotella DP - Search Results

1

N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE. Rotella DP, et al. J Med Chem. 2000 Apr 6;43(7):1257-63. doi: 10.1021/jm000081+. J Med Chem. 2000. PMID: 10753463

2

Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE. Rotella DP, et al. J Med Chem. 2000 Dec 28;43(26):5037-43. doi: 10.1021/jm000336j. J Med Chem. 2000. PMID: 11150175

3

Phosphodiesterase 5 inhibitors: current status and potential applications.

Rotella DP. Rotella DP. Nat Rev Drug Discov. 2002 Sep;1(9):674-82. doi: 10.1038/nrd893. Nat Rev Drug Discov. 2002. PMID: 12209148 Review.

4

Tadalafil Lilly ICOS.

Rotella DP. Rotella DP. Curr Opin Investig Drugs. 2003 Jan;4(1):60-5. Curr Opin Investig Drugs. 2003. PMID: 12625031 Review.

5

Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists.

Yang W, Wang Y, Roberge JY, Ma Z, Liu Y, Michael Lawrence R, Rotella DP, Seethala R, Feyen JH, Dickson JK Jr. Yang W, et al. Among authors: rotella dp. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1225-8. doi: 10.1016/j.bmcl.2004.11.071. Bioorg Med Chem Lett. 2005. PMID: 15686947

6

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

Simpkins LM, Bolton S, Pi Z, Sutton JC, Kwon C, Zhao G, Magnin DR, Augeri DJ, Gungor T, Rotella DP, Sun Z, Liu Y, Slusarchyk WS, Marcinkeviciene J, Robertson JG, Wang A, Robl JA, Atwal KS, Zahler RL, Parker RA, Kirby MS, Hamann LG. Simpkins LM, et al. Among authors: rotella dp. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6476-80. doi: 10.1016/j.bmcl.2007.09.090. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17937986

7

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.

Yan Y, Zhou P, Rotella DP, Feenstra R, Kruse CG, Reinders JH, van der Neut M, Lai M, Zhang J, Kowal DM, Carrick T, Marquis KL, Pausch MH, Robichaud AJ. Yan Y, et al. Among authors: rotella dp. Bioorg Med Chem Lett. 2010 May 1;20(9):2983-6. doi: 10.1016/j.bmcl.2010.02.105. Epub 2010 Mar 3. Bioorg Med Chem Lett. 2010. PMID: 20347298

8

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.

Mahmood SU, Lozano Gonzalez M, Tummalapalli S, Eberhard J, Ly J, Hoffman CS, Kelly MP, Gordon J, Colussi D, Childers W, Rotella DP. Mahmood SU, et al. Among authors: rotella dp. J Med Chem. 2023 Nov 9;66(21):14597-14608. doi: 10.1021/acs.jmedchem.3c01088. Epub 2023 Oct 20. J Med Chem. 2023. PMID: 37862143 Free PMC article.

9

First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders.

Mahmood SU, Eberhard J, Hoffman CS, Colussi D, Gordon J, Childers W, Amurrio E, Patel J, Kelly MP, Rotella DP. Mahmood SU, et al. Among authors: rotella dp. J Med Chem. 2024 Oct 10;67(19):17774-17784. doi: 10.1021/acs.jmedchem.4c01794. Epub 2024 Sep 25. J Med Chem. 2024. PMID: 39321314 Free PMC article.

10

Synthesis and P-388 antitumor properties of the four diastereomeric 1-hydroxy-3,4-diaminocyclohexane-Cl2PtII complexes.

Witiak DT, Rotella DP, Wei Y, Filppi JA, Gallucci JC. Witiak DT, et al. Among authors: rotella dp. J Med Chem. 1989 Jan;32(1):214-7. doi: 10.1021/jm00121a038. J Med Chem. 1989. PMID: 2909734

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