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Page 1
SRC homology-2 inhibitors: peptidomimetic and nonpeptide.
Sawyer TK, Bohacek RS, Dalgarno DC, Eyermann CJ, Kawahata N, Metcalf CA 3rd, Shakespeare WC, Sundaramoorthi R, Wang Y, Yang MG. Sawyer TK, et al. Among authors: bohacek rs. Mini Rev Med Chem. 2002 Oct;2(5):475-88. doi: 10.2174/1389557023405765. Mini Rev Med Chem. 2002. PMID: 12370048 Review.
Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.
Sundaramoorthi R, Shakespeare WC, Keenan TP, Metcalf CA 3rd, Wang Y, Mani U, Taylor M, Liu S, Bohacek RS, Narula SS, Dalgarno DC, van Schravandijk MR, Violette SM, Liou S, Adams S, Ram MK, Keats JA, Weigle M, Sawyer TK, Weigele M. Sundaramoorthi R, et al. Among authors: bohacek rs. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3063-6. doi: 10.1016/s0960-894x(03)00647-4. Bioorg Med Chem Lett. 2003. PMID: 12941334
Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases.
Wang Y, Metcalf CA 3rd, Shakespeare WC, Sundaramoorthi R, Keenan TP, Bohacek RS, van Schravendijk MR, Violette SM, Narula SS, Dalgarno DC, Haraldson C, Keats J, Liou S, Mani U, Pradeepan S, Ram M, Adams S, Weigele M, Sawyer TK. Wang Y, et al. Among authors: bohacek rs. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3067-70. doi: 10.1016/s0960-894x(03)00648-6. Bioorg Med Chem Lett. 2003. PMID: 12941335
Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.
Vu CB, Luke GP, Kawahata N, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keenan TP, Pradeepan S, Corpuz E, Merry T, Bohacek RS, Dalgarno DC, Narula SS, van Schravendijk MR, Ram MK, Adams S, Liou S, Keats JA, Violette SM, Guan W, Weigele M, Sawyer TK. Vu CB, et al. Among authors: bohacek rs. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3071-4. doi: 10.1016/s0960-894x(03)00649-8. Bioorg Med Chem Lett. 2003. PMID: 12941336
Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.
Shakespeare W, Yang M, Bohacek R, Cerasoli F, Stebbins K, Sundaramoorthi R, Azimioara M, Vu C, Pradeepan S, Metcalf C 3rd, Haraldson C, Merry T, Dalgarno D, Narula S, Hatada M, Lu X, van Schravendijk MR, Adams S, Violette S, Smith J, Guan W, Bartlett C, Herson J, Iuliucci J, Weigele M, Sawyer T. Shakespeare W, et al. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9373-8. doi: 10.1073/pnas.97.17.9373. Proc Natl Acad Sci U S A. 2000. PMID: 10944210 Free PMC article.
Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.
Vu CB, Corpuz EG, Merry TJ, Pradeepan SG, Bartlett C, Bohacek RS, Botfield MC, Eyermann CJ, Lynch BA, MacNeil IA, Ram MK, van Schravendijk MR, Violette S, Sawyer TK. Vu CB, et al. Among authors: bohacek rs. J Med Chem. 1999 Oct 7;42(20):4088-98. doi: 10.1021/jm990229t. J Med Chem. 1999. PMID: 10514279
41 results