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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A. Clapham JC, et al. Among authors: smith sa. Nature. 2000 Jul 27;406(6794):415-8. doi: 10.1038/35019082. Nature. 2000. PMID: 10935638
Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.
Young PW, Cawthorne MA, Coyle PJ, Holder JC, Holman GD, Kozka IJ, Kirkham DM, Lister CA, Smith SA. Young PW, et al. Among authors: smith sa. Diabetes. 1995 Sep;44(9):1087-92. doi: 10.2337/diab.44.9.1087. Diabetes. 1995. PMID: 7657033
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.
Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. Young PW, et al. Among authors: smith sa. J Pharmacol Exp Ther. 1998 Feb;284(2):751-9. J Pharmacol Exp Ther. 1998. PMID: 9454824
1,631 results