Esnouf RM - Search Results

1

Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.

Ren J, Esnouf RM, Hopkins AL, Stuart DI, Stammers DK. Ren J, et al. Among authors: esnouf rm. J Med Chem. 1999 Sep 23;42(19):3845-51. doi: 10.1021/jm990275t. J Med Chem. 1999. PMID: 10508433

2

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.

Esnouf R, Ren J, Ross C, Jones Y, Stammers D, Stuart D. Esnouf R, et al. Nat Struct Biol. 1995 Apr;2(4):303-8. doi: 10.1038/nsb0495-303. Nat Struct Biol. 1995. PMID: 7540935

3

The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design.

Ren J, Esnouf R, Hopkins A, Ross C, Jones Y, Stammers D, Stuart D. Ren J, et al. Structure. 1995 Sep 15;3(9):915-26. doi: 10.1016/S0969-2126(01)00226-X. Structure. 1995. PMID: 8535785 Free article.

4

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.

Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI. Hopkins AL, et al. Among authors: esnouf rm. J Med Chem. 1996 Apr 12;39(8):1589-600. doi: 10.1021/jm960056x. J Med Chem. 1996. PMID: 8648598

5

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.

Esnouf RM, Ren J, Hopkins AL, Ross CK, Jones EY, Stammers DK, Stuart DI. Esnouf RM, et al. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. doi: 10.1073/pnas.94.8.3984. Proc Natl Acad Sci U S A. 1997. PMID: 9108091 Free PMC article.

6

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.

Ren J, Esnouf RM, Hopkins AL, Jones EY, Kirby I, Keeling J, Ross CK, Larder BA, Stuart DI, Stammers DK. Ren J, et al. Among authors: esnouf rm. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. doi: 10.1073/pnas.95.16.9518. Proc Natl Acad Sci U S A. 1998. PMID: 9689112 Free PMC article.

7

Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration.

Esnouf RM, Ren J, Garman EF, Somers DO, Ross CK, Jones EY, Stammers DK, Stuart DI. Esnouf RM, et al. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):938-53. doi: 10.1107/s0907444998004284. Acta Crystallogr D Biol Crystallogr. 1998. PMID: 9757109

8

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.

Ren J, Esnouf RM, Hopkins AL, Warren J, Balzarini J, Stuart DI, Stammers DK. Ren J, et al. Among authors: esnouf rm. Biochemistry. 1998 Oct 13;37(41):14394-403. doi: 10.1021/bi981309m. Biochemistry. 1998. PMID: 9772165

9

Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.

Ren J, Diprose J, Warren J, Esnouf RM, Bird LE, Ikemizu S, Slater M, Milton J, Balzarini J, Stuart DI, Stammers DK. Ren J, et al. Among authors: esnouf rm. J Biol Chem. 2000 Feb 25;275(8):5633-9. doi: 10.1074/jbc.275.8.5633. J Biol Chem. 2000. PMID: 10681546 Free article.

10

High resolution structures of HIV-1 RT from four RT-inhibitor complexes.

Ren J, Esnouf R, Garman E, Somers D, Ross C, Kirby I, Keeling J, Darby G, Jones Y, Stuart D, et al. Ren J, et al. Nat Struct Biol. 1995 Apr;2(4):293-302. doi: 10.1038/nsb0495-293. Nat Struct Biol. 1995. PMID: 7540934

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