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Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412).
Giardina GA, Raveglia LF, Grugni M, Sarau HM, Farina C, Medhurst AD, Graziani D, Schmidt DB, Rigolio R, Luttmann M, Cavagnera S, Foley JJ, Vecchietti V, Hay DW. Giardina GA, et al. Among authors: graziani d. J Med Chem. 1999 Mar 25;42(6):1053-65. doi: 10.1021/jm980633c. J Med Chem. 1999. PMID: 10090788
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.
Graziani D, Caligari S, Callegari E, De Toma C, Longhi M, Frigerio F, Dilernia R, Menegon S, Pinzi L, Pirona L, Tazzari V, Valsecchi AE, Vistoli G, Rastelli G, Riva C. Graziani D, et al. J Med Chem. 2019 Feb 14;62(3):1246-1273. doi: 10.1021/acs.jmedchem.8b01226. Epub 2019 Jan 28. J Med Chem. 2019. PMID: 30624919
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
Anighoro A, Graziani D, Bettinelli I, Cilia A, De Toma C, Longhi M, Mangiarotti F, Menegon S, Pirona L, Poggesi E, Riva C, Rastelli G. Anighoro A, et al. Among authors: graziani d. Bioorg Med Chem. 2015 Jul 1;23(13):3040-58. doi: 10.1016/j.bmc.2015.05.008. Epub 2015 May 12. Bioorg Med Chem. 2015. PMID: 26014480
Paracoccidioides lutzii Infects Galleria mellonella Employing Formamidase as a Virulence Factor.
Pereira ED, Moreira TR, Cruz-Leite VRM, Tomazett MV, Souza Silva LO, Graziani D, Martins JA, Amaral AC, Weber SS, Parente-Rocha JA, Soares CMA, Borges CL. Pereira ED, et al. Among authors: graziani d. PLoS Negl Trop Dis. 2024 Sep 3;18(9):e0012452. doi: 10.1371/journal.pntd.0012452. eCollection 2024 Sep. PLoS Negl Trop Dis. 2024. PMID: 39226308 Free PMC article.
62 results