De Clercq E - Search Results

1

Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.

Degrève B, De Clercq E, Balzarini J. Degrève B, et al. Among authors: de clercq e. Gene Ther. 1999 Feb;6(2):162-70. doi: 10.1038/sj.gt.3300806. Gene Ther. 1999. PMID: 10435100

2

Differential affinities of pyrimidine nucleoside analogues for deoxythymidine and deoxycytidine kinase determine their incorporation into murine leukemia L1210 cells.

Balzarini J, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Acta Biochim Pol. 1987;34(2):63-77. Acta Biochim Pol. 1987. PMID: 2823514

3

Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.

Balzarini J, Morin KW, Knaus EE, Wiebe LI, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Gene Ther. 1995 Jul;2(5):317-22. Gene Ther. 1995. PMID: 7671107

4

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.

Bohman C, Balzarini J, Wigerinck P, Van Aerschot A, Herdewijn P, De Clercq E. Bohman C, et al. Among authors: de clercq e. J Biol Chem. 1994 Mar 18;269(11):8036-43. J Biol Chem. 1994. PMID: 8132526 Free article.

5

Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.

Balzarini J, Bohman C, De Clercq E. Balzarini J, et al. Among authors: de clercq e. J Biol Chem. 1993 Mar 25;268(9):6332-7. J Biol Chem. 1993. PMID: 8384209 Free article.

6

Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.

Degrève B, Andrei G, Izquierdo M, Piette J, Morin K, Knaus EE, Wiebe LI, Basrah I, Walker RT, De Clercq E, Balzarini J. Degrève B, et al. Among authors: de clercq e. Gene Ther. 1997 Oct;4(10):1107-14. doi: 10.1038/sj.gt.3300502. Gene Ther. 1997. PMID: 9415318

7

Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.

Balzarini J, Degrève B, Andrei G, Neyts J, Sandvold M, Myhren F, de Clercq E. Balzarini J, et al. Among authors: de clercq e. Gene Ther. 1998 Mar;5(3):419-26. doi: 10.1038/sj.gt.3300586. Gene Ther. 1998. PMID: 9614564

8

Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK.

Degrève B, Johansson M, De Clercq E, Karlsson A, Balzarini J. Degrève B, et al. Among authors: de clercq e. J Virol. 1998 Dec;72(12):9535-43. doi: 10.1128/JVI.72.12.9535-9543.1998. J Virol. 1998. PMID: 9811686 Free PMC article.

9

Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy.

Wera S, Degrève B, Balzarini J, De Clercq E, Thevelein JM, Neyts J. Wera S, et al. Among authors: de clercq e. Biotechniques. 1999 Oct;27(4):772-4, 776-7. doi: 10.2144/99274st08. Biotechniques. 1999. PMID: 10524320 Free article.

10

Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).

Degrève B, De Clercq E, Balzarini J. Degrève B, et al. Among authors: de clercq e. Gene Ther. 2000 Sep;7(18):1543-52. doi: 10.1038/sj.gt.3301278. Gene Ther. 2000. PMID: 11021592

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