Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A

F Zeng; H Jiang; X Tang; K Chen; R Ji

doi:10.1016/s0960-894x(98)00280-7

Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1661-4. doi: 10.1016/s0960-894x(98)00280-7.

Authors

F Zeng¹, H Jiang, X Tang, K Chen, R Ji

Affiliation

¹ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

PMID: 9873409
DOI: 10.1016/s0960-894x(98)00280-7

Abstract

The synthesis of (+/-)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (-)-huperzine A.

MeSH terms

Animals
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / pharmacology*
Hippocampus / drug effects
Hippocampus / enzymology
Rats
Sesquiterpenes / chemical synthesis*
Sesquiterpenes / pharmacology*

Substances

14-fluorohuperzine A
Cholinesterase Inhibitors
Sesquiterpenes