Fibre-fluorescence in situ hybridization unravels apparently seven DAZ genes or pseudogenes clustered within a Y-chromosome region frequently deleted in azoospermic males

Chromosome Res. 1998 Sep;6(6):481-6. doi: 10.1023/a:1009256613348.

Abstract

Using the technique of 'fibre-FISH' (fluorescence in situ hybridization), we describe the direct visualization of seven longer DAZ signal stretches and in addition a maximum of four isolated single DAZ signals on Y-chromatin fibres of four different individuals. These seven longer DAZ signal stretches may represent seven DAZ genes or pseudogenes, whereas the single DAZ signals may represent truncated DAZ genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Deleted in Azoospermia 1 Protein
  • Heterochromatin / genetics
  • Humans
  • In Situ Hybridization, Fluorescence / methods*
  • Male
  • Multigene Family
  • Oligospermia / genetics*
  • Pseudogenes*
  • RNA-Binding Proteins / genetics*
  • Y Chromosome*

Substances

  • DAZ1 protein, human
  • Deleted in Azoospermia 1 Protein
  • Heterochromatin
  • RNA-Binding Proteins