Abstract
1. Microsomal P450 and peroxisomal fatty acid oxidation activities were studied in liver of rats after long-term ethanol consumption. 2. Ethanol increased the microsomal lauric acid omega-hydroxylation and the aminopyrine N-demethylation catalyzed by cytochrome P450. 3. Ethanol increased peroxisomal beta-oxidation of palmitoyl CoA and catalase activity in liver. 4. Both microsomal and peroxisomal activities behaved in a coordinate way in the liver of rats with long-term ethanol consumption. 5. These results would support a role of microsomal omega-hydroxylation and peroxisomal beta-oxidation of fatty acids in an extramitochondrial pathway of lipid oxidation in the liver.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Drinking / metabolism*
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Alcohol Drinking / pathology
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Aminopyrine / metabolism
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Animals
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Catalase / metabolism
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Cytochrome P-450 Enzyme System / metabolism
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Fatty Acids / metabolism*
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Hydroxylation
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Lauric Acids / metabolism
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Lipid Peroxidation
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Liver / enzymology
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Liver / metabolism*
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Liver / ultrastructure
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Male
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Microbodies / enzymology
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Microbodies / metabolism*
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Microsomes, Liver / enzymology
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Microsomes, Liver / metabolism*
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Oxidation-Reduction
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Palmitoyl Coenzyme A / metabolism
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Rats
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Rats, Wistar
Substances
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Fatty Acids
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Lauric Acids
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Aminopyrine
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lauric acid
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Palmitoyl Coenzyme A
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Cytochrome P-450 Enzyme System
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Catalase