Purpose: Small bowel adenocarcinoma is a rare cancer and usually occurs in elderly males. A 12-year-old girl with metastatic small bowel adenocarcinoma and her clinical course are described. The difficulties in making the pathologic diagnosis and the literature are also reviewed.
Patients and methods: A 12-year-old girl had partial small bowel obstruction and bilateral ovarian enlargement. Exploratory laparotomy revealed a jejunal tumor with bilateral ovarian involvement and extensive peritoneal and pelvic studding. The pathologic diagnosis of small bowel adenocarcinoma was made.
Results: The patient had a moderate response to therapy with 5-fluorouracil, leucovorin, and alpha-interferon before developing progressive disease unresponsive to therapy with topotecan, taxol, or carboplatin. She survived for 23 months after diagnosis.
Conclusion: Making an accurate diagnosis of tumors metastatic to the ovary can be difficult and requires attention to histologic detail. Small bowel adenocarcinoma is usually a chemoresistant tumor with extremely poor outcome. This patient had a moderate response to chemotherapy and a prolonged survival compared to that of patients previously reported.